{"doi":"10.1371/journal.pgph.0003608","title":"Attrition in serum anti-DENV antibodies correlates with high anti-SARS-CoV-2 IgG levels and low DENV positivity in mosquito vectors—Findings from a state-wide cluster-randomized community-based study in Tamil Nadu, India","abstract":"The decline in dengue incidence and/or prevalence during the COVID-19 pandemic (2020-22) appears to be attributed to reduced treatment-seeking rates, under-reporting, misdiagnosis, disrupted health services and reduced exposure to mosquito vectors due to prevailing lockdowns. There is limited scientific data on dengue virus (DENV) disease during the COVID-19 pandemic. Here, we conducted a community-based, cross-sectional, cluster-randomized survey to assess anti-DENV and anti-SARS-CoV-2 seroprevalence, and also estimated the spatial distribution of DENV-positive aedine mosquito vectors during the COVID-19 pandemic across all the 38 districts of Tamil Nadu, India. Using real-time PCR, the prevalence of DENV in mosquito pools during 2021 was analyzed and compared with the previous and following years of vector surveillance, and correlated with anti-DENV IgM and IgG levels in the population. Results implicate that both anti-DENV IgM and IgG seroprevalence and DENV positivity in mosquito pools were reduced across all the districts. A total of 13464 mosquito pools and 5577 human serum samples from 186 clusters were collected. Of these, 3.76% of the mosquito pools were positive for DENV. In the human sera, 4.12% were positive for anti-DENV IgM and 6.4% for anti-DENV IgG. While the anti-SARS-CoV-2 levels significantly correlated with overall DENV seropositivity, COVID-19 vaccination status significantly correlated with anti-DENV IgM levels. The study indicates a profound impact of anti-SARS-CoV-2 levels on DENV-positive mosquito pools and seropositivity. Continuous monitoring of anti-DENV antibody levels, especially with the evolving variants of SARS-CoV-2 and the surge in COVID-19 cases will shed light on the distribution, transmission and therapeutic attributes of DENV infection.","journal":"PLOS Global Public Health","year":2024,"id":469888,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9526,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1252815,"name":"Sathish Sankar","orcid":"0000-0002-9389-5231","position":1,"is_corresponding":false},{"id":435766,"name":"Yean K. Yong","orcid":"0000-0002-8409-6251","position":2,"is_corresponding":false},{"id":1049147,"name":"Abdul R. Anshad","orcid":null,"position":3,"is_corresponding":false},{"id":1049146,"name":"Samudi Chandramathi","orcid":null,"position":4,"is_corresponding":false},{"id":1303959,"name":"Anavarathan Somasundaram","orcid":null,"position":5,"is_corresponding":false},{"id":1049149,"name":"Sampath Palani","orcid":null,"position":6,"is_corresponding":false},{"id":1303496,"name":"Parthipan Kumarasamy","orcid":"0000-0003-4971-6854","position":7,"is_corresponding":false},{"id":1303960,"name":"Roshini Azhaguvel","orcid":null,"position":8,"is_corresponding":false},{"id":1303497,"name":"Ajith Prabhu Kumar","orcid":"0000-0001-8805-1088","position":9,"is_corresponding":false},{"id":1303498,"name":"Sudharshini Subramaniam","orcid":"0000-0001-8632-5065","position":10,"is_corresponding":false},{"id":1303961,"name":"Manickam Malathi","orcid":null,"position":11,"is_corresponding":false},{"id":1303962,"name":"V. Vijayalakshmi","orcid":null,"position":12,"is_corresponding":false},{"id":1049142,"name":"Manivannan Rajeshkumar","orcid":null,"position":13,"is_corresponding":false},{"id":1049145,"name":"Anandhazhvar Kumaresan","orcid":null,"position":14,"is_corresponding":false},{"id":1031223,"name":"Ramendra Pati Pandey","orcid":"0000-0002-5196-6468","position":15,"is_corresponding":false},{"id":1303499,"name":"Nagarajan Muruganandam","orcid":"0000-0003-0430-221X","position":16,"is_corresponding":false},{"id":1048495,"name":"Natarajan Gopalan","orcid":"0000-0002-6521-1744","position":17,"is_corresponding":false},{"id":1048494,"name":"Meganathan Kannan","orcid":"0000-0002-6107-4228","position":18,"is_corresponding":false},{"id":364797,"name":"Amudhan Murugesan","orcid":"0000-0003-4713-2927","position":19,"is_corresponding":false},{"id":432913,"name":"Pachamuthu Balakrishnan","orcid":"0000-0002-1710-9155","position":20,"is_corresponding":false},{"id":69434,"name":"Siddappa N. Byrareddy","orcid":"0000-0002-6889-4640","position":21,"is_corresponding":false},{"id":61102,"name":"Aditya Prasad Dash","orcid":"0000-0002-8414-2000","position":22,"is_corresponding":false},{"id":280890,"name":"Vijayakumar Velu","orcid":"0000-0003-4238-1924","position":23,"is_corresponding":false},{"id":435768,"name":"Marie Larsson","orcid":"0000-0002-4524-0177","position":24,"is_corresponding":false},{"id":340123,"name":"Esaki M. Shankar","orcid":"0000-0002-7866-9818","position":25,"is_corresponding":false},{"id":961492,"name":"Sivadoss Raju","orcid":"0000-0002-0524-2979","position":26,"is_corresponding":false},{"id":1049140,"name":"Sivaprakasam T. Selvavinayagam","orcid":null,"position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-19T02:05:32.241298Z","pmid":"39570962","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}