{"doi":"10.1371/journal.pgph.0000828","title":"Performance of highly sensitive and conventional rapid diagnostic tests for clinical and subclinical Plasmodium falciparum infections, and hrp2/3 deletion status in Burundi","abstract":"Rapid diagnostic tests (RDTs) are a key tool for the diagnosis of malaria infections among clinical and subclinical individuals. Low-density infections, and deletions of the P. falciparum hrp2/3 genes (encoding the HRP2 and HRP3 proteins detected by many RDTs) present challenges for RDT-based diagnosis. The novel Rapigen Biocredit three-band Plasmodium falciparum HRP2/LDH RDT was evaluated among 444 clinical and 468 subclinical individuals in a high transmission setting in Burundi. Results were compared to the AccessBio CareStart HRP2 RDT, and qPCR with a sensitivity of <0.3 parasites/μL blood. Sensitivity compared to qPCR among clinical patients for the Biocredit RDT was 79.9% (250/313, either of HRP2/LDH positive), compared to 73.2% (229/313) for CareStart (P = 0.048). Specificity of the Biocredit was 82.4% compared to 96.2% for CareStart. Among subclinical infections, sensitivity was 72.3% (162/224) compared to 58.5% (131/224) for CareStart (P = 0.003), and reached 88.3% (53/60) in children <15 years. Specificity was 84.4% for the Biocredit and 93.4% for the CareStart RDT. No (0/362) hrp2 and 2/366 hrp3 deletions were observed. In conclusion, the novel RDT showed improved sensitivity for the diagnosis of P. falciparum.","journal":"PLOS Global Public Health","year":2022,"id":250039,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9632,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":892198,"name":"Denis Sinzinkayo","orcid":null,"position":1,"is_corresponding":false},{"id":728775,"name":"Emma V. Troth","orcid":"0000-0002-5879-7695","position":2,"is_corresponding":false},{"id":712982,"name":"Colins O. Oduma","orcid":"0000-0001-9678-8143","position":3,"is_corresponding":false},{"id":892199,"name":"Mediatrice Barengayabo","orcid":null,"position":4,"is_corresponding":false},{"id":892200,"name":"Mireille Ndereyimana","orcid":null,"position":5,"is_corresponding":false},{"id":329222,"name":"Aurel Holzschuh","orcid":"0000-0002-2681-1114","position":6,"is_corresponding":false},{"id":810157,"name":"Claudia A. Vera-Arias","orcid":"0009-0004-7835-2644","position":7,"is_corresponding":false},{"id":892201,"name":"Yilekal Gebre","orcid":null,"position":8,"is_corresponding":false},{"id":729968,"name":"Kingsley Badu","orcid":"0000-0002-7886-5528","position":9,"is_corresponding":false},{"id":891435,"name":"Joseph Nyandwi","orcid":"0000-0002-3715-7891","position":10,"is_corresponding":false},{"id":892202,"name":"Dismas Baza","orcid":null,"position":11,"is_corresponding":false},{"id":892203,"name":"Elizabeth Juma","orcid":null,"position":12,"is_corresponding":false},{"id":341335,"name":"Cristian Koepfli","orcid":"0000-0002-9354-0414","position":13,"is_corresponding":false},{"id":891434,"name":"David Niyukuri","orcid":"0000-0002-2112-4999","position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":null,"created_at":"2026-07-19T00:24:28.242323Z","pmid":"36962426","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}