{"doi":"10.1371/journal.pgen.1011228","title":"Into the Wild: A novel wild-derived inbred strain resource expands the genomic and phenotypic diversity of laboratory mouse models","abstract":"The laboratory mouse has served as the premier animal model system for both basic and preclinical investigations for over a century. However, laboratory mice capture only a subset of the genetic variation found in wild mouse populations, ultimately limiting the potential of classical inbred strains to uncover phenotype-associated variants and pathways. Wild mouse populations are reservoirs of genetic diversity that could facilitate the discovery of new functional and disease-associated alleles, but the scarcity of commercially available, well-characterized wild mouse strains limits their broader adoption in biomedical research. To overcome this barrier, we have recently developed, sequenced, and phenotyped a set of 11 inbred strains derived from wild-caught Mus musculus domesticus. Each of these \"Nachman strains\" immortalizes a unique wild haplotype sampled from one of five environmentally distinct locations across North and South America. Whole genome sequence analysis reveals that each strain carries between 4.73-6.54 million single nucleotide differences relative to the GRCm39 mouse reference, with 42.5% of variants in the Nachman strain genomes absent from current classical inbred mouse strain panels. We phenotyped the Nachman strains on a customized pipeline to assess the scope of disease-relevant neurobehavioral, biochemical, physiological, metabolic, and morphological trait variation. The Nachman strains exhibit significant inter-strain variation in >90% of 1119 surveyed traits and expand the range of phenotypic diversity captured in classical inbred strain panels. These novel wild-derived inbred mouse strain resources are set to empower new discoveries in both basic and preclinical research.","journal":"PLoS Genetics","year":2024,"id":423701,"datarank":0.6055433991829858,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"self_citation_contribution":0.47670807455219194,"citation_network_contribution":0.12883532463079392,"self_endowment_contribution":0.47670807455219194,"citer_contribution":0.12883532463079392,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":13,"citers_with_citation_signal":10,"citers_with_endowment":10,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6559,"is_data_producer":true,"deposit_databanks":{"SRA":["PRJNA1037121"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":76214,"name":"Daniel M. Gatti","orcid":"0000-0003-0667-9926","position":1,"is_corresponding":false},{"id":761964,"name":"Mallory A. Ballinger","orcid":"0000-0003-3087-0608","position":2,"is_corresponding":false},{"id":1217353,"name":"Dana Lin","orcid":"0000-0002-7952-2359","position":3,"is_corresponding":false},{"id":350938,"name":"Megan Phifer‐Rixey","orcid":"0000-0002-3804-6229","position":4,"is_corresponding":false},{"id":363354,"name":"Michael J. Sheehan","orcid":"0000-0002-3949-7873","position":5,"is_corresponding":false},{"id":350936,"name":"Taichi A. Suzuki","orcid":"0000-0001-7800-8596","position":6,"is_corresponding":false},{"id":768974,"name":"Lydia K. Wooldridge","orcid":"0000-0001-6285-9142","position":7,"is_corresponding":false},{"id":1220029,"name":"Hilda Opoku Frempong","orcid":null,"position":8,"is_corresponding":false},{"id":401646,"name":"Raman Akinyanju Lawal","orcid":"0000-0001-8908-7664","position":9,"is_corresponding":false},{"id":76209,"name":"Gary A. Churchill","orcid":"0000-0001-9190-9284","position":10,"is_corresponding":false},{"id":275066,"name":"Cathleen Lutz","orcid":"0000-0003-2502-1900","position":11,"is_corresponding":false},{"id":268613,"name":"Nadia Rosenthal","orcid":"0000-0002-7599-7365","position":12,"is_corresponding":false},{"id":399269,"name":"Jacqueline K. White","orcid":"0000-0001-6268-2826","position":13,"is_corresponding":false},{"id":350939,"name":"Michael W. Nachman","orcid":"0000-0003-4321-5135","position":14,"is_corresponding":false},{"id":401644,"name":"Beth L. Dumont","orcid":"0000-0003-0918-0389","position":0,"is_corresponding":true}],"reference_count":91,"raw_metadata":null,"created_at":"2026-07-19T01:58:01.889748Z","pmid":"38598567","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}