{"doi":"10.1371/journal.pgen.1010352","title":"Posttranslational regulation of the GCN5 and PCAF acetyltransferases","abstract":"<jats:p>General control nonderepressible 5 protein (Gcn5) and its homologs, including p300/CBP-associated factor (PCAF), are lysine acetyltransferases that modify both histone and non-histone proteins using acetyl coenzyme A as a donor substrate. While decades of studies have uncovered a vast network of cellular processes impacted by these acetyltransferases, including gene transcription and metabolism, far less is known about how these enzymes are themselves regulated. In this review, we summarize the type and functions of posttranslational modifications proposed to control Gcn5 in both yeast and human cells. We further outline common themes, open questions, and strategies to guide future work.</jats:p>","journal":"PLOS Genetics","year":2022,"id":14948,"datarank":0.5823471028390151,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.209611105370815,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.209611105370815,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":11,"citers_with_citation_signal":8,"citers_with_endowment":8,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":115418,"name":"Michael Downey","orcid":"0000-0002-5234-6666","position":1,"is_corresponding":false},{"id":115907,"name":"Onyekachi E. Ononye","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36107838","pmcid":"PMC9477270","openalex_id":"https://openalex.org/W4295897911","authors":[],"funders":[{"funder_name":"NSERC","grant_id":"RGPIN-2021-03887","title":null},{"funder_name":"Natural Sciences and Engineering Research Council of Canada","grant_id":"unidentified","title":"unidentified"}],"total_grants":2,"fwci":0.8662,"citation_percentile":0.71440033,"influential_citations":0,"citation_trend":[{"year":2023,"count":3},{"year":2024,"count":5},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010352&type=printable","host_type":"journal"},{"url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010352&type=printable","host_type":"GOLD"},{"url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010352&type=printable","host_type":"publisher"},{"url":"https://dx.plos.org/10.1371/journal.pgen.1010352","host_type":"publisher"},{"url":"https://doi.org/10.1371/journal.pgen.1010352","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36107838","host_type":"repository"},{"url":"https://doaj.org/article/0df93b0d97324deba355cd7069cab622","host_type":"repository"},{"url":"https://doaj.org/article/ad1bc8df57eb452e99e37daed635ca70","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9477270","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9477270","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9477270?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1371/journal.pgen.1010352","host_type":""}],"fields_of_study":["Ubiquitin and proteasome pathways","Protein Degradation and Inhibitors","Epigenetics and DNA Methylation","Medicine","Biology","Chemistry","0301 basic medicine","0303 health sciences","03 medical and health sciences","Acetyl Coenzyme A","Acetylation","Acetyltransferases","Histones","Humans","Protein Processing, Post-Translational"],"mesh_terms":["Acetyl Coenzyme A","Acetylation","Acetyltransferases","Histones","Humans","Protein Processing, Post-Translational"],"keywords":["PCAF","Histone Acetyltransferases","Acetyltransferases","Biology","P300-CBP Transcription Factors","Acetylation","Histone","Acetyltransferase","Genetics","Transcription factor","Computational biology","Biochemistry","Cell biology","Gene","Histones","Acetyl Coenzyme A","Humans","Review","QH426-470","Protein Processing, Post-Translational"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-01T15:41:54.660136Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}