{"doi":"10.1371/journal.pgen.1009494","title":"Putting the brakes on centromere drive in Mimulus","abstract":"Asymmetric female meiosis in plants and animals is a battleground. Homologous chromosomes compete with each other for transmission through meiosis based on their centromeric DNA that recruits the chromosome segregation apparatus. Larger centromeres may recruit more centromeric proteins (centromere strength) and segregate into eggs more often than expected by mendelian inheritance (\"centromere drive\") This subversion of female meiosis by \"selfish centromeres\" can be harmful and lower host fitness. Therefore, suppressors of centromere drive are predicted to arise, especially in centromeric proteins like CenH3/CENP-A. There is ample support for the first step of centromere drive [2-4], with one of the best demonstrations coming from studies in Mimulus monkeyflowers, in which a centromeric variant locus (D) undergoes centromere drive in interspecies and intraspecies crosses However, evidence of the second step of the model, i.e., suppression of centromere drive by centromeric proteins, remains elusive. A new study by Finseth and colleagues It also reveals genetic variation in susceptibility to drive within M. guttatus, including a modifier of drive that maps to a CenH3 paralog, which adaptively evolved after the driving D centromere.","journal":"PLoS Genetics","year":2021,"id":211797,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9533,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":341208,"name":"Harmit S. Malik","orcid":"0000-0001-6005-0016","position":1,"is_corresponding":false},{"id":557279,"name":"Ching-Ho Chang","orcid":"0000-0001-9361-1190","position":0,"is_corresponding":true}],"reference_count":17,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:52:23.670339Z","pmid":"33886542","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}