{"doi":"10.1371/journal.pgen.1008313","title":"RPW8/HR repeats control NLR activation in Arabidopsis thaliana","abstract":"In many plant species, conflicts between divergent elements of the immune system, especially nucleotide-binding oligomerization domain-like receptors (NLR), can lead to hybrid necrosis. Here, we report deleterious allele-specific interactions between an NLR and a non-NLR gene cluster, resulting in not one, but multiple hybrid necrosis cases in Arabidopsis thaliana. The NLR cluster is RESISTANCE TO PERONOSPORA PARASITICA 7 (RPP7), which can confer strain-specific resistance to oomycetes. The non-NLR cluster is RESISTANCE TO POWDERY MILDEW 8 (RPW8) / HOMOLOG OF RPW8 (HR), which can confer broad-spectrum resistance to both fungi and oomycetes. RPW8/HR proteins contain at the N-terminus a potential transmembrane domain, followed by a specific coiled-coil (CC) domain that is similar to a domain found in pore-forming toxins MLKL and HET-S from mammals and fungi. C-terminal to the CC domain is a variable number of 21- or 14-amino acid repeats, reminiscent of regulatory 21-amino acid repeats in fungal HET-S. The number of repeats in different RPW8/HR proteins along with the sequence of a short C-terminal tail predicts their ability to activate immunity in combination with specific RPP7 partners. Whether a larger or smaller number of repeats is more dangerous depends on the specific RPW8/HR autoimmune risk variant.","journal":"PLOS Genetics","year":2019,"id":11325,"datarank":2.024351980951191,"base_score":4.343805421853684,"endowment":4.343805421853684,"self_citation_contribution":0.6515708132780527,"citation_network_contribution":1.3727811676731385,"self_endowment_contribution":0.6515708132780527,"citer_contribution":1.3727811676731385,"corpus_percentile":null,"corpus_rank":null,"citation_count":76,"citer_count":57,"citers_with_citation_signal":52,"citers_with_endowment":52,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0499,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2019-07-25","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":91366,"name":"Rui Wu","orcid":"0000-0002-2348-8059","position":1,"is_corresponding":false},{"id":91367,"name":"Sang-Tae Kim","orcid":"0000-0003-1645-6021","position":2,"is_corresponding":false},{"id":91368,"name":"Wanyan Xi","orcid":null,"position":3,"is_corresponding":false},{"id":91369,"name":"Anette Habring","orcid":"0000-0001-5447-9975","position":4,"is_corresponding":false},{"id":91370,"name":"Jörg Hagmann","orcid":"0000-0002-7232-3103","position":5,"is_corresponding":false},{"id":18788,"name":"Anna-Lena Van de Weyer","orcid":"0000-0002-5180-897X","position":6,"is_corresponding":false},{"id":91371,"name":"Maricris Zaidem","orcid":"0000-0002-1913-6771","position":7,"is_corresponding":false},{"id":91372,"name":"William Wing Ho Ho","orcid":"0000-0002-7360-2243","position":8,"is_corresponding":false},{"id":91373,"name":"George Wang","orcid":"0000-0001-5214-9382","position":9,"is_corresponding":false},{"id":91374,"name":"Ilja Bezrukov","orcid":"0000-0003-0420-4329","position":10,"is_corresponding":false},{"id":6849,"name":"Detlef Weigel","orcid":"0000-0002-2114-7963","position":11,"is_corresponding":false},{"id":6850,"name":"Eunyoung Chae","orcid":"0000-0002-0889-9837","position":12,"is_corresponding":false},{"id":6842,"name":"Ana Cristina Barragan","orcid":"0000-0003-1656-9261","position":13,"is_corresponding":false}],"reference_count":73,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}