{"doi":"10.1371/journal.pgen.1005727","title":"Skp1 Independent Function of Cdc53/Cul1 in F-box Protein Homeostasis","abstract":null,"journal":"PLOS Genetics","year":2015,"id":606041,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1555601,"name":"James L. Yen","orcid":null,"position":1,"is_corresponding":false},{"id":1275696,"name":"Peter Kaiser","orcid":"0000-0002-7814-4552","position":2,"is_corresponding":false},{"id":284048,"name":"Radhika Mathur","orcid":"0000-0002-3346-1781","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Skp1 Independent Function of Cdc53/Cul1 in F-box Protein Homeostasis","abstract":"Abundance of substrate receptor subunits of Cullin-RING ubiquitin ligases (CRLs) is tightly controlled to maintain the full repertoire of CRLs. Unbalanced levels can lead to sequestration of CRL core components by a few overabundant substrate receptors. Numerous diseases, including cancer, have been associated with misregulation of substrate receptor components, particularly for the largest class of CRLs, the SCF ligases. One relevant mechanism that controls abundance of their substrate receptors, the F-box proteins, is autocatalytic ubiquitylation by intact SCF complex followed by proteasome-mediated degradation. Here we describe an additional pathway for regulation of F-box proteins on the example of yeast Met30. This ubiquitylation and degradation pathway acts on Met30 that is dissociated from Skp1. Unexpectedly, this pathway required the cullin component Cdc53/Cul1 but was independent of the other central SCF component Skp1. We demonstrated that this non-canonical degradation pathway is critical for chromosome stability and effective defense against heavy metal stress. More importantly, our results assign important biological functions to a sub-complex of cullin-RING ligases that comprises Cdc53/Rbx1/Cdc34, but is independent of Skp1.","is_dataset_classified":null,"base_score":2.302585092994046,"endowment":2.302585092994046,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26656496","pmcid":"PMC4675558","openalex_id":"https://openalex.org/W2191672636","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM066164","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R56 GM066164","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"GM-066164-S1","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"GM-066164","title":null},{"funder_name":"National Institutes of Health","grant_id":"2R01GM066164-18","title":"Ubiquitin Signaling"}],"total_grants":5,"fwci":0.1478,"citation_percentile":0.56666982,"influential_citations":0,"citation_trend":[{"year":2018,"count":1},{"year":2020,"count":4},{"year":2022,"count":2},{"year":2024,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1005727&type=printable","host_type":"journal"},{"url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1005727&type=printable","host_type":"publisher"},{"url":"http://dx.plos.org/10.1371/journal.pgen.1005727","host_type":"publisher"},{"url":"https://doi.org/10.1371/journal.pgen.1005727","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26656496","host_type":"repository"},{"url":"https://doaj.org/article/d4923af01ff5425f9c2081aaf72efc71","host_type":"repository"},{"url":"https://escholarship.org/uc/item/4760f11z","host_type":"repository"},{"url":"https://figshare.com/articles/dataset/_Skp1_Independent_Function_of_Cdc53_Cul1_in_F_box_Protein_Homeostasis_/1622442","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4675558","host_type":"repository"},{"url":"http://www.escholarship.org/uc/item/4760f11z","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC4675558","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC4675558?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1371/journal.pgen.1005727","host_type":""},{"url":"https://dx.doi.org/10.1371/journal.pgen.1005727","host_type":""},{"url":"https://doi.org/https://doi.org/10.1371/journal.pgen.1005727","host_type":""}],"fields_of_study":["Ubiquitin and proteasome pathways","Autophagy in Disease and Therapy","Endoplasmic Reticulum Stress and Disease","0301 basic medicine","03 medical and health sciences","0303 health sciences","Amino Acid Sequence","Cadmium","Cell Cycle","Cell Division","Cullin Proteins","F-Box Proteins","Homeostasis","Metabolic Networks and Pathways","Proteolysis","SKP Cullin F-Box Protein Ligases","Saccharomyces cerevisiae","Saccharomyces cerevisiae Proteins","Ubiquitin-Protein Ligase Complexes","Ubiquitination","Ubiquitins"],"mesh_terms":["Amino Acid Sequence","Cadmium","Cell Cycle","Cell Division","Homeostasis","Saccharomyces cerevisiae","Ubiquitins","Saccharomyces cerevisiae Proteins","Ubiquitin-Protein Ligase Complexes","F-Box Proteins","Cullin Proteins","SKP Cullin F-Box Protein Ligases","Metabolic Networks and Pathways","Ubiquitination","Proteolysis"],"keywords":["Skp1","Cullin","F-box protein","Biology","Cell division control protein 4","Ubiquitin ligase","Ubiquitin","Cell biology","Protein degradation","COP9 signalosome","Ubiquitin-Protein Ligases","Proteasome","Receptor","Biochemistry","Enzyme","Gene","Protease","Saccharomyces cerevisiae Proteins","Life on Land","1.1 Normal biological development and functioning","Saccharomyces cerevisiae","QH426-470","Underpinning research","Genetics","Homeostasis","Amino Acid Sequence","Ubiquitins","SKP Cullin F-Box Protein Ligases","F-Box Proteins","Cell Cycle","Ubiquitination","Ubiquitin-Protein Ligase Complexes","Cullin Proteins","Proteolysis","Generic health relevance","Cell Division","Metabolic Networks and Pathways","Developmental Biology","Research Article","Cadmium"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. Good health"},{"sdg_number":16,"sdg_label":"16. Peace & justice"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T03:46:20.385234Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}