{"doi":"10.1371/journal.pgen.1005446","title":"The Wnt Frizzled Receptor MOM-5 Regulates the UNC-5 Netrin Receptor through Small GTPase-Dependent Signaling to Determine the Polarity of Migrating Cells","abstract":null,"journal":"PLOS Genetics","year":2015,"id":612040,"datarank":0.7691286964253634,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"self_citation_contribution":0.47670807455219194,"citation_network_contribution":0.2924206218731714,"self_endowment_contribution":0.47670807455219194,"citer_contribution":0.2924206218731714,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":21,"citers_with_citation_signal":12,"citers_with_endowment":12,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1575648,"name":"Meghan Krizus","orcid":null,"position":1,"is_corresponding":false},{"id":274620,"name":"Hong Zheng","orcid":"0000-0001-5802-330X","position":2,"is_corresponding":false},{"id":490899,"name":"Louise Brown","orcid":"0000-0002-1327-6482","position":3,"is_corresponding":false},{"id":1490470,"name":"Joseph G. Culotti","orcid":"0000-0001-6325-4612","position":4,"is_corresponding":false},{"id":1490467,"name":"Naomi Levy-Strumpf","orcid":"0000-0002-5454-8800","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The Wnt Frizzled Receptor MOM-5 Regulates the UNC-5 Netrin Receptor through Small GTPase-Dependent Signaling to Determine the Polarity of Migrating Cells","abstract":"Wnt and Netrin signaling regulate diverse essential functions. Using a genetic approach combined with temporal gene expression analysis, we found a regulatory link between the Wnt receptor MOM-5/Frizzled and the UNC-6/Netrin receptor UNC-5. These two receptors play key roles in guiding cell and axon migrations, including the migration of the C. elegans Distal Tip Cells (DTCs). DTCs migrate post-embryonically in three sequential phases: in the first phase along the Antero-Posterior (A/P) axis, in the second, along the Dorso-Ventral (D/V) axis, and in the third, along the A/P axis. Loss of MOM-5/Frizzled function causes third phase A/P polarity reversals of the migrating DTCs. We show that an over-expression of UNC-5 causes similar DTC A/P polarity reversals and that unc-5 deficits markedly suppress the A/P polarity reversals caused by mutations in mom-5/frizzled. This implicates MOM-5/Frizzled as a negative regulator of unc-5. We provide further evidence that small GTPases mediate MOM-5's regulation of unc-5 such that one outcome of impaired function of small GTPases like CED-10/Rac and MIG-2/RhoG is an increase in unc-5 function. The work presented here demonstrates the existence of cross talk between components of the Netrin and Wnt signaling pathways and provides further insights into the way guidance signaling mechanisms are integrated to orchestrate directed cell migration.","is_dataset_classified":null,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26292279","pmcid":"PMC4546399","openalex_id":"https://openalex.org/W1667270153","authors":[],"funders":[{"funder_name":"Canadian Institutes of Health Research","grant_id":"MOP 77722","title":null},{"funder_name":"Canadian Institutes of Health Research","grant_id":"MOP 119505","title":null},{"funder_name":"Canadian Institutes of Health Research","grant_id":"MOP 13207","title":null},{"funder_name":"Canadian Institutes of Health Research","grant_id":"unidentified","title":"unidentified"}],"total_grants":4,"fwci":0.9037,"citation_percentile":0.67709062,"influential_citations":3,"citation_trend":[{"year":2016,"count":3},{"year":2017,"count":3},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2021,"count":1},{"year":2022,"count":1},{"year":2023,"count":3},{"year":2024,"count":4},{"year":2025,"count":6}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1005446&type=printable","host_type":"journal"},{"url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1005446&type=printable","host_type":"GOLD"},{"url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1005446&type=printable","host_type":"publisher"},{"url":"http://dx.plos.org/10.1371/journal.pgen.1005446","host_type":"publisher"},{"url":"https://doi.org/10.1371/journal.pgen.1005446","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26292279","host_type":"repository"},{"url":"https://doaj.org/article/6296950d00ba4d84af4f2e761145cddf","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4546399","host_type":"repository"},{"url":"https://figshare.com/articles/dataset/_The_Wnt_Frizzled_Receptor_MOM_5_Regulates_the_UNC_5_Netrin_Receptor_through_Small_GTPase_Dependent_Signaling_to_Determine_the_Polarity_of_Migrating_Cells_/1515691","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC4546399","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC4546399?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1371/journal.pgen.1005446","host_type":""},{"url":"https://dx.doi.org/10.1371/journal.pgen.1005446","host_type":""}],"fields_of_study":["Axon Guidance and Neuronal Signaling","Wnt/β-catenin signaling in development and cancer","Congenital heart defects research","Biology","Medicine","0301 basic medicine","0303 health sciences","03 medical and health sciences","Animals","Caenorhabditis elegans","Caenorhabditis elegans Proteins","Cell Movement","Cell Polarity","Gene Expression","Membrane Proteins","Neurons","Receptors, Cell Surface","Signal Transduction","Transcription, Genetic","rac GTP-Binding Proteins"],"mesh_terms":["Animals","Cell Movement","Membrane Proteins","Neurons","Receptors, Cell Surface","Transcription, Genetic","Signal Transduction","Gene Expression","Cell Polarity","Caenorhabditis elegans","rac GTP-Binding Proteins","Caenorhabditis elegans Proteins"],"keywords":["Frizzled","Biology","Wnt signaling pathway","Cell biology","Netrin","Cell polarity","Small GTPase","LRP6","Polarity (international relations)","GTPase","Signal transduction","Receptor","GTPase-activating protein","Dishevelled","Genetics","Axon guidance","G protein","Cell","Neurons","Transcription, Genetic","Gene Expression","Membrane Proteins","Receptors, Cell Surface","QH426-470","rac GTP-Binding Proteins","Cell Movement","Animals","Caenorhabditis elegans","Caenorhabditis elegans Proteins","Research Article"],"sdg_mappings":[{"sdg_number":10,"sdg_label":"10. 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