{"doi":"10.1371/journal.pgen.1003357","title":"Pax6 Regulates Gene Expression in the Vertebrate Lens through miR-204","abstract":null,"journal":"PLoS Genetics","year":2013,"id":664264,"datarank":3.2965942485517727,"base_score":4.727387818712341,"endowment":4.727387818712341,"self_citation_contribution":0.7091081728068512,"citation_network_contribution":2.5874860757449216,"self_endowment_contribution":0.7091081728068512,"citer_contribution":2.5874860757449216,"corpus_percentile":null,"corpus_rank":null,"citation_count":112,"citer_count":85,"citers_with_citation_signal":80,"citers_with_endowment":80,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1734463,"name":"Karen Gueta","orcid":null,"position":1,"is_corresponding":false},{"id":1734464,"name":"Eyal Mor","orcid":null,"position":2,"is_corresponding":false},{"id":1734465,"name":"Pazit Oren-Giladi","orcid":null,"position":3,"is_corresponding":false},{"id":1734466,"name":"Dina Grinberg","orcid":null,"position":4,"is_corresponding":false},{"id":588202,"name":"Qing Xie","orcid":"0000-0002-8547-8892","position":5,"is_corresponding":false},{"id":141376,"name":"Ales Cvekl","orcid":null,"position":6,"is_corresponding":false},{"id":430506,"name":"Noam Shomron","orcid":"0000-0001-9913-6124","position":7,"is_corresponding":false},{"id":1734467,"name":"Noa Davis","orcid":null,"position":8,"is_corresponding":false},{"id":1734468,"name":"Maya Keydar-Prizant","orcid":null,"position":9,"is_corresponding":false},{"id":1695600,"name":"Shaul Raviv","orcid":null,"position":10,"is_corresponding":false},{"id":211422,"name":"Metsada Pasmanik-Chor","orcid":null,"position":11,"is_corresponding":false},{"id":766951,"name":"Rachel E. 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Recent studies have established a dual role for the transcription factor Pax6 as both an activator and repressor of gene expression in the eye, central nervous system, and pancreas. However, the molecular mechanism underlying the inhibitory activity of Pax6 is not fully understood. Here, we reveal that Trpm3 and the intronic microRNA gene miR-204 are co-regulated by Pax6 during eye development. miR-204 is probably the best known microRNA to function as a negative modulator of gene expression during eye development in vertebrates. Analysis of genes altered in mouse Pax6 mutants during lens development revealed significant over-representation of miR-204 targets among the genes up-regulated in the Pax6 mutant lens. A number of new targets of miR-204 were revealed, among them Sox11, a member of the SoxC family of pro-neuronal transcription factors, and an important regulator of eye development. Expression of Trpm/miR-204 and a few of its targets are also Pax6-dependent in medaka fish eyes. Collectively, this study identifies a novel evolutionarily conserved mechanism by which Pax6 controls the down-regulation of multiple genes through direct up-regulation of miR-204.","is_dataset_classified":null,"base_score":4.727387818712341,"endowment":4.727387818712341,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23516376","pmcid":"PMC3597499","openalex_id":"https://openalex.org/W1963867421","authors":[],"funders":[{"funder_name":"Telethon","grant_id":"TGM06D01","title":null},{"funder_name":"Telethon","grant_id":"GFP03007","title":null},{"funder_name":"NEI NIH HHS","grant_id":"R01 EY012200","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01EY012200-04","title":"PAX-6 AS A KEY REGULATOR OF LENS DEVELOPMENT"}],"total_grants":4,"fwci":4.3357,"citation_percentile":0.95081967,"influential_citations":0,"citation_trend":[{"year":2013,"count":3},{"year":2014,"count":16},{"year":2015,"count":17},{"year":2016,"count":7},{"year":2017,"count":4},{"year":2018,"count":5},{"year":2019,"count":5},{"year":2020,"count":10},{"year":2021,"count":6},{"year":2022,"count":5},{"year":2023,"count":8},{"year":2024,"count":13},{"year":2025,"count":10},{"year":2026,"count":3}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1003357&type=printable","host_type":"journal"},{"url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1003357&type=printable","host_type":"publisher"},{"url":"http://dx.plos.org/10.1371/journal.pgen.1003357","host_type":"publisher"},{"url":"https://doi.org/10.1371/journal.pgen.1003357","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23516376","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3597499","host_type":"repository"},{"url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.790.5910","host_type":""},{"url":"https://doaj.org/article/bf6213e6196d4a98b2d6d64730153543","host_type":"repository"},{"url":"https://figshare.com/articles/Pax6_Regulates_Gene_Expression_in_the_Vertebrate_Lens_through_miR_204__/652587","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3597499","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC3597499?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1371/journal.pgen.1003357","host_type":""},{"url":"http://hdl.handle.net/11588/785020","host_type":""},{"url":"http://www.plosgenetics.org/article/fetchObjectAttachment.action?uri=info:doi/10.1371/journal.pgen.1003357&representation=PDF","host_type":""},{"url":"https://dx.doi.org/10.1371/journal.pgen.1003357","host_type":""},{"url":"https://hdl.handle.net/11588/785020","host_type":""},{"url":"http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1003357","host_type":""},{"url":"https://hdl.handle.net/11591/183229","host_type":""}],"fields_of_study":["MicroRNA in disease regulation","Connexins and lens biology","Circular RNAs in diseases","0301 basic medicine","03 medical and health sciences","0303 health sciences","Animals","Binding Sites","Cell Differentiation","Crystallins","Evolution, Molecular","Eye","Eye Proteins","Gene Expression Regulation","Gene Expression Regulation, Developmental","Homeodomain Proteins","Mice","MicroRNAs","PAX6 Transcription Factor","Paired Box Transcription Factors","Repressor Proteins","SOXC Transcription Factors","TRPM Cation Channels","Vertebrates"],"mesh_terms":["PAX6 Transcription Factor","Animals","Binding Sites","Cell Differentiation","Crystallins","Eye","Eye Proteins","Gene Expression Regulation","Repressor Proteins","Vertebrates","Homeodomain Proteins","Gene Expression Regulation, Developmental","Evolution, Molecular","MicroRNAs","TRPM Cation Channels","Mice","Paired Box Transcription Factors","SOXC Transcription Factors"],"keywords":["PAX6","Biology","Transcription factor","Regulation of gene expression","Gene","Genetics","Eye development","microRNA","Gene expression","Repressor","Cell biology","PAX6 Transcription Factor","Evolution","TRPM Cation Channels","QH426-470","Eye","SOXC Transcription Factors","Evolution, Molecular","Mice","Animals","Paired Box Transcription Factors","Developmental","Eye Proteins","Homeodomain Proteins","Binding Sites","Molecular","Gene Expression Regulation, Developmental","Cell Differentiation","Crystallins","Repressor Proteins","MicroRNAs","Gene Expression Regulation","Animals; Binding Sites; Cell Differentiation; Crystallins; Gene Expression Regulation; Gene Expression Regulation, Developmental; Mice; PAX6 Transcription Factor; SOXC Transcription Factors; TRPM Cation Channels; Vertebrates; Evolution, Molecular; Eye; Eye Proteins; Homeodomain Proteins; MicroRNAs; Paired Box Transcription Factors; Repressor Proteins","Vertebrates","Research Article"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-13T01:51:42.029204Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}