{"doi":"10.1371/journal.pgen.1002548","title":"Comprehensive Research Synopsis and Systematic Meta-Analyses in Parkinson's Disease Genetics: The PDGene Database","abstract":"More than 800 published genetic association studies have implicated dozens of potential risk loci in Parkinson's disease (PD). To facilitate the interpretation of these findings, we have created a dedicated online resource, PDGene, that comprehensively collects and meta-analyzes all published studies in the field. A systematic literature screen of -27,000 articles yielded 828 eligible articles from which relevant data were extracted. In addition, individual-level data from three publicly available genome-wide association studies (GWAS) were obtained and subjected to genotype imputation and analysis. Overall, we performed meta-analyses on more than seven million polymorphisms originating either from GWAS datasets and/or from smaller scale PD association studies. Meta-analyses on 147 SNPs were supplemented by unpublished GWAS data from up to 16,452 PD cases and 48,810 controls. Eleven loci showed genome-wide significant (P < 5 × 10(-8)) association with disease risk: BST1, CCDC62/HIP1R, DGKQ/GAK, GBA, LRRK2, MAPT, MCCC1/LAMP3, PARK16, SNCA, STK39, and SYT11/RAB25. In addition, we identified novel evidence for genome-wide significant association with a polymorphism in ITGA8 (rs7077361, OR 0.88, P  =  1.3 × 10(-8)). All meta-analysis results are freely available on a dedicated online database (www.pdgene.org), which is cross-linked with a customized track on the UCSC Genome Browser. Our study provides an exhaustive and up-to-date summary of the status of PD genetics research that can be readily scaled to include the results of future large-scale genetics projects, including next-generation sequencing studies.","journal":"PLoS Genetics","year":2012,"id":4088,"datarank":8.951228781489926,"base_score":6.29156913955832,"endowment":6.29156913955832,"self_citation_contribution":0.9437353709337482,"citation_network_contribution":8.007493410556178,"self_endowment_contribution":0.9437353709337482,"citer_contribution":8.007493410556178,"corpus_percentile":76.81041497152157,"corpus_rank":286,"citation_count":543,"citer_count":143,"citers_with_citation_signal":143,"citers_with_endowment":143,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.92,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2012-03-15","algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":18036,"name":"Johannes T. 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