{"doi":"10.1371/journal.pgen.1001148","title":"Widespread Over-Expression of the X Chromosome in Sterile F1 Hybrid Mice","abstract":null,"journal":"PLoS Genetics","year":2010,"id":610232,"datarank":0.7278045395879427,"base_score":4.852030263919617,"endowment":4.852030263919617,"self_citation_contribution":0.7278045395879427,"citation_network_contribution":0.0,"self_endowment_contribution":0.7278045395879427,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":127,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":32852,"name":"Thomas Giger","orcid":null,"position":1,"is_corresponding":false},{"id":520725,"name":"Matthew D. Dean","orcid":"0000-0002-5601-4140","position":2,"is_corresponding":false},{"id":350939,"name":"Michael W. Nachman","orcid":"0000-0003-4321-5135","position":3,"is_corresponding":false},{"id":7667,"name":"Jeffrey M. Good","orcid":"0000-0003-0707-5374","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Widespread Over-Expression of the X Chromosome in Sterile F1 Hybrid Mice","abstract":"The X chromosome often plays a central role in hybrid male sterility between species, but it is unclear if this reflects underlying regulatory incompatibilities. Here we combine phenotypic data with genome-wide expression data to directly associate aberrant expression patterns with hybrid male sterility between two species of mice. We used a reciprocal cross in which F₁ males are sterile in one direction and fertile in the other direction, allowing us to associate expression differences with sterility rather than with other hybrid phenotypes. We found evidence of extensive over-expression of the X chromosome during spermatogenesis in sterile but not in fertile F₁ hybrid males. Over-expression was most pronounced in genes that are normally expressed after meiosis, consistent with an X chromosome-wide disruption of expression during the later stages of spermatogenesis. This pattern was not a simple consequence of faster evolutionary divergence on the X chromosome, because X-linked expression was highly conserved between the two species. Thus, transcriptional regulation of the X chromosome during spermatogenesis appears particularly sensitive to evolutionary divergence between species. Overall, these data provide evidence for an underlying regulatory basis to reproductive isolation in house mice and underscore the importance of transcriptional regulation of the X chromosome to the evolution of hybrid male sterility.","is_dataset_classified":null,"base_score":4.852030263919617,"endowment":4.852030263919617,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20941395","pmcid":"PMC2947990","openalex_id":"https://openalex.org/W2121950969","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"F32 GM070246","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"F32GM070246-02","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"1R01 GM074245-01A1","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM074245","title":null},{"funder_name":"National Science Foundation","grant_id":"0213013","title":"Collaborative Research:Dynamics of Genes in Mouse Hybrid Zones"},{"funder_name":"National Institutes of Health","grant_id":"5F32GM070246-03","title":"EVOLUTIONARY GENETICS OF MALE REPRODUCTIVE TRAITS IN MUS"},{"funder_name":"National Science Foundation","grant_id":"0754461","title":"International Research Fellowship Program: Evolutionary Reproductive Genomics in Humans and Great Apes"},{"funder_name":"National Institutes of Health","grant_id":"5R01GM074245-03","title":"Natural selection and DNA sequence variation in Mus"},{"funder_name":"National Science Foundation","grant_id":"0608452","title":"DISSERTATION RESEARCH: The Genetic Basis of Reproductive Isolation Among Two Species of House Mice"}],"total_grants":9,"fwci":6.3228,"citation_percentile":0.97090392,"influential_citations":0,"citation_trend":[{"year":2012,"count":16},{"year":2013,"count":7},{"year":2014,"count":12},{"year":2015,"count":5},{"year":2016,"count":17},{"year":2017,"count":9},{"year":2018,"count":10},{"year":2019,"count":3},{"year":2020,"count":7},{"year":2021,"count":8},{"year":2022,"count":5},{"year":2023,"count":6},{"year":2024,"count":6},{"year":2025,"count":1},{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1001148&type=printable","host_type":"journal"},{"url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1001148&type=printable","host_type":"publisher"},{"url":"http://dx.plos.org/10.1371/journal.pgen.1001148","host_type":"publisher"},{"url":"https://doi.org/10.1371/journal.pgen.1001148","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/20941395","host_type":"repository"},{"url":"https://scholarworks.umt.edu/biosci_pubs/75","host_type":"journal"},{"url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.351.2976","host_type":""},{"url":"https://doaj.org/article/0795f7cea5df451193bb14e01fb79cab","host_type":"repository"},{"url":"http://edoc.mpg.de/499428","host_type":"repository"},{"url":"https://figshare.com/articles/Widespread_Over_Expression_of_the_X_Chromosome_in_Sterile_F_1_Hybrid_Mice/141363","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2947990","host_type":"repository"},{"url":"http://hdl.handle.net/11858/00-001M-0000-000F-F5FF-D","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC2947990","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC2947990?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1371/journal.pgen.1001148","host_type":""},{"url":"https://dx.doi.org/10.1371/journal.pgen.1001148","host_type":""},{"url":"https://hdl.handle.net/11858/00-001M-0000-000F-F5FF-D","host_type":""},{"url":"https://hdl.handle.net/11858/00-001M-0000-0019-B522-F","host_type":""}],"fields_of_study":["Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","Sperm and Testicular Function","Genomics and Chromatin Dynamics","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Animals","Chimera","Crosses, Genetic","Biological Evolution","Female","Infertility, Male","Male","Species Specificity","Testis","X Chromosome","Epigenesis, Genetic","X Chromosome Inactivation","Mice"],"keywords":["Biology","Sterility","Genetics","X chromosome","Gene","Chromosome","Meiosis","Phenotype","Y chromosome","Reproductive isolation","Regulation of gene expression","Gene expression","Research Article"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in 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