{"doi":"10.1371/journal.pbio.3003490","title":"The cell cycle regulator PLK1 promotes murine melanoma progression by regulating the transcription factor BACH1","abstract":"Polo-like kinase 1 (PLK1), a critical cell cycle regulator, is associated with cancer progression and negatively correlates with patient survival in cutaneous melanoma based on clinical database analysis. In a melanoma mouse model induced by BRafCA mutation and Pten-deficiency, we observed that PLK1 overexpression mediated metabolic reprogramming to markedly accelerate tumor growth, promote metastasis, and shortened mice survival. Mechanistically, PLK1 stabilizes BTB domain and CNC homolog 1 (BACH1), which serves as a crucial transcription factor for genes involved in cancer metabolism and metastasis. Moreover, the PLK1/BACH1 axis confers resistance to Vemurafenib, a BRAFV600E inhibitor, in melanoma. In light of this finding, we attempted an innovative pharmacological combination targeting both BRAFV600E and PLK1, identifying a synergistic efficiency to this approach to suppress tumor growth. Overall, we have discovered a novel function of PLK1 that is independent of the cell cycle, which could pave new ways for melanoma therapies.","journal":"PLoS Biology","year":2025,"id":527612,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.956,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1129571,"name":"Sai Wu","orcid":"0000-0002-1866-9197","position":1,"is_corresponding":false},{"id":567667,"name":"Derek B. Allison","orcid":"0000-0002-5119-2474","position":2,"is_corresponding":false},{"id":271896,"name":"Daheng He","orcid":"0000-0003-0399-2466","position":3,"is_corresponding":false},{"id":411938,"name":"Yifan Kong","orcid":"0000-0002-5650-8079","position":4,"is_corresponding":false},{"id":411937,"name":"Chaohao Li","orcid":"0000-0001-5975-3937","position":5,"is_corresponding":false},{"id":1129572,"name":"Zhiguo Li","orcid":"0000-0002-8546-9750","position":6,"is_corresponding":false},{"id":411940,"name":"Yanquan Zhang","orcid":"0000-0003-3527-9972","position":7,"is_corresponding":false},{"id":919743,"name":"Xinyi Wang","orcid":"0000-0002-7389-6018","position":8,"is_corresponding":false},{"id":747532,"name":"Qiongsi Zhang","orcid":"0000-0002-6234-5034","position":9,"is_corresponding":false},{"id":1447,"name":"Chi Wang","orcid":"0000-0001-8984-4995","position":10,"is_corresponding":false},{"id":411943,"name":"Xiaoqi Liu","orcid":"0000-0002-6613-1746","position":11,"is_corresponding":false},{"id":411939,"name":"Fengyi Mao","orcid":"0000-0001-7785-6606","position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":null,"created_at":"2026-07-19T02:50:39.280101Z","pmid":"41284701","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}