{"doi":"10.1371/journal.pbio.3002481","title":"Tracing the evolutionary origins of antiviral immunity","abstract":"Recent discoveries characterizing bacterial antiphage defense systems have generated a surprising observation: Bacteria and human cells use strikingly similar mechanisms to protect against viral infection As founding examples, key components of human immunity including cyclic GMP-AMP synthase (cGAS), stimulator of interferon genes (STING), and viperin each originated in ancient antiviral systems of bacteria and archaea In animal cells, cGAS and other cGLRs (cGAS-like receptors) sense foreign nucleic acid and catalyze synthesis of nucleotide immune signals including 2 0 3 0 -cGAMP (2 0 -5 0 /3 0 -5 0 cyclic GMP-AMP). 2 0 3 0 -cGAMP activates the downstream receptor STING and induces antiviral responses through type I interferon and NF-B signaling Type I interferons can induce expression of a suite of antiviral effector proteins including the enzyme viperin that creates chain-terminating nucleotide analogs that potently inhibit viral transcription and genome replication","journal":"PLoS Biology","year":2024,"id":463589,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9489,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":230272,"name":"Philip J. Kranzusch","orcid":"0000-0002-4943-733X","position":1,"is_corresponding":false},{"id":317962,"name":"James B. Eaglesham","orcid":"0000-0002-5725-0743","position":0,"is_corresponding":true}],"reference_count":11,"raw_metadata":null,"created_at":"2026-07-19T02:04:33.257852Z","pmid":"38319913","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}