{"doi":"10.1371/journal.pbio.3000981","title":"Acetylation-mediated remodeling of the nucleolus regulates cellular acetyl-CoA responses","abstract":"The metabolite acetyl-coenzyme A (acetyl-CoA) serves as an essential element for a wide range of cellular functions including adenosine triphosphate (ATP) production, lipid synthesis, and protein acetylation. Intracellular acetyl-CoA concentrations are associated with nutrient availability, but the mechanisms by which a cell responds to fluctuations in acetyl-CoA levels remain elusive. Here, we generate a cell system to selectively manipulate the nucleo-cytoplasmic levels of acetyl-CoA using clustered regularly interspaced short palindromic repeat (CRISPR)-mediated gene editing and acetate supplementation of the culture media. Using this system and quantitative omics analyses, we demonstrate that acetyl-CoA depletion alters the integrity of the nucleolus, impairing ribosomal RNA synthesis and evoking the ribosomal protein-dependent activation of p53. This nucleolar remodeling appears to be mediated through the class IIa histone deacetylases (HDACs). Our findings highlight acetylation-mediated control of the nucleolus as an important hub linking acetyl-CoA fluctuations to cellular stress responses.","journal":"PLoS Biology","year":2020,"id":95631,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":36,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.958,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":299706,"name":"Shiori Sekine","orcid":"0000-0001-9962-833X","position":1,"is_corresponding":false},{"id":307519,"name":"Michael Calderon","orcid":"0000-0002-0820-7888","position":2,"is_corresponding":false},{"id":268695,"name":"Fayaz Seifuddin","orcid":"0000-0003-3357-7888","position":3,"is_corresponding":false},{"id":475030,"name":"Guanghui Wang","orcid":"0000-0001-8551-6468","position":4,"is_corresponding":false},{"id":475031,"name":"Hiroyuki Kawagishi","orcid":"0000-0001-7622-341X","position":5,"is_corresponding":false},{"id":324618,"name":"Daniela Malide","orcid":null,"position":6,"is_corresponding":false},{"id":314730,"name":"Yuesheng Li","orcid":"0000-0002-1393-3913","position":7,"is_corresponding":false},{"id":284426,"name":"Marjan Guček","orcid":"0000-0001-7890-2520","position":8,"is_corresponding":false},{"id":268694,"name":"Mehdi Pirooznia","orcid":"0000-0002-4210-6458","position":9,"is_corresponding":false},{"id":260651,"name":"Alissa J. Nelson","orcid":"0000-0003-3622-6944","position":10,"is_corresponding":false},{"id":261611,"name":"Matthew P. Stokes","orcid":null,"position":11,"is_corresponding":false},{"id":343793,"name":"Jacob Stewart-Ornstein","orcid":"0000-0001-8255-5904","position":12,"is_corresponding":false},{"id":237068,"name":"Steven J. Mullett","orcid":"0009-0005-6971-9288","position":13,"is_corresponding":false},{"id":237076,"name":"Stacy G. Wendell","orcid":"0000-0001-9083-6933","position":14,"is_corresponding":false},{"id":279286,"name":"Simon C. Watkins","orcid":"0000-0003-4092-1552","position":15,"is_corresponding":false},{"id":271028,"name":"Toren Finkel","orcid":"0000-0002-0726-3546","position":16,"is_corresponding":false},{"id":475032,"name":"Yusuke Sekine","orcid":"0000-0003-0345-1416","position":17,"is_corresponding":false},{"id":475029,"name":"Ryan Houston","orcid":"0000-0001-9494-2514","position":0,"is_corresponding":true}],"reference_count":103,"raw_metadata":null,"created_at":"2026-07-18T22:33:57.534608Z","pmid":"33253182","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}