{"doi":"10.1371/journal.pbio.3000164","title":"Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen","abstract":null,"journal":"PLOS Biology","year":2019,"id":604686,"datarank":1.1644677630116298,"base_score":3.713572066704308,"endowment":3.713572066704308,"self_citation_contribution":0.5570358100056463,"citation_network_contribution":0.6074319530059835,"self_endowment_contribution":0.5570358100056463,"citer_contribution":0.6074319530059835,"corpus_percentile":null,"corpus_rank":null,"citation_count":40,"citer_count":24,"citers_with_citation_signal":20,"citers_with_endowment":20,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1511038,"name":"Marie Galloux","orcid":"0000-0001-7477-8489","position":1,"is_corresponding":false},{"id":1551562,"name":"Sabrina S. 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However, many pathogens (e.g., respiratory syncytial virus [RSV], influenza, dengue, and others) have resisted vaccine development efforts, largely because of the failure to induce potent antibody responses targeting conserved epitopes. Deep profiling of human B cells often reveals potent neutralizing antibodies that emerge from natural infection, but these specificities are generally subdominant (i.e., are present in low titers). A major challenge for next-generation vaccines is to overcome established immunodominance hierarchies and focus antibody responses on crucial neutralization epitopes. Here, we show that a computationally designed epitope-focused immunogen presenting a single RSV neutralization epitope elicits superior epitope-specific responses compared to the viral fusion protein. In addition, the epitope-focused immunogen efficiently boosts antibodies targeting the palivizumab epitope, resulting in enhanced neutralization. Overall, we show that epitope-focused immunogens can boost subdominant neutralizing antibody responses in vivo and reshape established antibody hierarchies.","is_dataset_classified":null,"base_score":3.713572066704308,"endowment":3.713572066704308,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30789898","pmcid":null,"openalex_id":"https://openalex.org/W2949246477","authors":[],"funders":[{"funder_name":"SystemsX","grant_id":"-","title":null},{"funder_name":"H2020 European Research Council","grant_id":"716058","title":null},{"funder_name":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","grant_id":"310030_163139","title":null}],"total_grants":3,"fwci":3.6676,"citation_percentile":0.93659582,"influential_citations":0,"citation_trend":[{"year":2019,"count":3},{"year":2020,"count":7},{"year":2021,"count":7},{"year":2022,"count":8},{"year":2023,"count":1},{"year":2024,"count":7},{"year":2025,"count":5},{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3000164&type=printable","host_type":"journal"},{"url":"https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3000164&type=printable","host_type":"publisher"},{"url":"http://dx.plos.org/10.1371/journal.pbio.3000164","host_type":"publisher"},{"url":"https://doi.org/10.1371/journal.pbio.3000164","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30789898","host_type":"repository"},{"url":"https://hal.inrae.fr/hal-04671074","host_type":"repository"},{"url":"https://inserm.hal.science/inserm-02138858","host_type":"repository"},{"url":"https://doaj.org/article/bea6dfa8a79f40869e4c2d0a5963a80d","host_type":"repository"},{"url":"http://europepmc.org/pmc/articles/PMC6400402","host_type":"repository"},{"url":"https://figshare.com/articles/dataset/Boosting_subdominant_neutralizing_antibody_responses_with_a_computationally_designed_epitope-focused_immunogen/7754132","host_type":"repository"},{"url":"http://infoscience.epfl.ch/record/264900","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6400402","host_type":"repository"}],"fields_of_study":["Respiratory viral infections research","Immune Cell Function and Interaction","Influenza Virus Research Studies"],"mesh_terms":["Palivizumab","Immunogenicity, Vaccine","Animals","Antibodies, Viral","Epitopes","Cloning, Molecular","Escherichia coli","Female","Genetic Vectors","Immunization","Mice, Inbred BALB C","Receptors, Antigen, B-Cell","Recombinant Fusion Proteins","Respiratory Syncytial Viruses","Viral Fusion Proteins","Gene Expression","Computer-Aided Design","Respiratory Syncytial Virus Vaccines","Structural Homology, Protein","Mice","Nanoparticles","Antibodies, Neutralizing","Antibodies, Monoclonal, Humanized"],"keywords":["Subdominant","Immunogen","Epitope","Biology","Virology","Neutralization","Neutralizing antibody","Antibody","Immunodominance","Dengue vaccine","Epitope mapping","Dengue virus","Immunology","Monoclonal antibody","Virus"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T00:42:42.549765Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}