{"doi":"10.1371/journal.pbio.2006203","title":"Unsolved mysteries: How does lipid peroxidation cause ferroptosis?","abstract":null,"journal":"PLOS Biology","year":2018,"id":591897,"datarank":10.711477105316686,"base_score":6.639875833826536,"endowment":6.639875833826536,"self_citation_contribution":0.9959813750739805,"citation_network_contribution":9.715495730242704,"self_endowment_contribution":0.9959813750739805,"citer_contribution":9.715495730242704,"corpus_percentile":null,"corpus_rank":null,"citation_count":764,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":90272,"name":"Brent R. 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First, the drivers of lipid peroxidation are not yet clear. Second, the subcellular location of lethal lipid peroxides remains an outstanding question. Finally, how exactly lipid peroxidation leads to cell death is an unsolved mystery. Answers to these questions will provide insights into the mechanisms of ferroptotic cell death and associated human diseases, as well as new therapeutic strategies for such diseases.","is_dataset_classified":null,"base_score":6.639875833826536,"endowment":6.639875833826536,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29795546","pmcid":"PMC5991413","openalex_id":"https://openalex.org/W2803347838","authors":[],"funders":[{"funder_name":"NCI NIH HHS","grant_id":"R35 CA209896","title":null},{"funder_name":"NCI NIH HHS","grant_id":"P01 CA087497","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R35CA209896-03","title":"Defining the functions and translational potential of ferroptosis"},{"funder_name":"National Institutes of Health","grant_id":"1P01CA087497-01","title":"ROLES AND REGULATION OF P53"}],"total_grants":4,"fwci":36.2432,"citation_percentile":0.9985372,"influential_citations":0,"citation_trend":[{"year":2018,"count":4},{"year":2019,"count":55},{"year":2020,"count":65},{"year":2021,"count":103},{"year":2022,"count":121},{"year":2023,"count":137},{"year":2024,"count":122},{"year":2025,"count":110},{"year":2026,"count":47}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.2006203&type=printable","host_type":"journal"},{"url":"https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.2006203&type=printable","host_type":"publisher"},{"url":"http://dx.plos.org/10.1371/journal.pbio.2006203","host_type":"publisher"},{"url":"https://doi.org/10.1371/journal.pbio.2006203","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29795546","host_type":"repository"},{"url":"https://doi.org/10.7916/D8572VKQ","host_type":"repository"},{"url":"https://doaj.org/article/255652d9cc1b4e7c880c131bf61438c6","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5991413","host_type":"repository"},{"url":"https://doi.org/10.7916/d8572vkq","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC5991413","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC5991413?pdf=render","host_type":"Europe_PMC"},{"url":"https://dx.doi.org/10.7916/d8572vkq","host_type":""},{"url":"http://dx.doi.org/10.1371/journal.pbio.2006203","host_type":""},{"url":"https://dx.doi.org/10.1371/journal.pbio.2006203","host_type":""},{"url":"https://doi.org/https://doi.org/10.7916/D8572VKQ","host_type":""}],"fields_of_study":["Ferroptosis and cancer prognosis","Cancer, Lipids, and Metabolism","Cholesterol and Lipid Metabolism","0301 basic medicine","0303 health sciences","03 medical and health sciences","Cell Death","Glutathione Peroxidase","Humans","Lipid Peroxidation","Lipoxygenases","Phospholipid Hydroperoxide Glutathione Peroxidase"],"mesh_terms":["Phospholipid Hydroperoxide Glutathione Peroxidase","Glutathione Peroxidase","Humans","Lipid Peroxidation","Cell Death","Lipoxygenases"],"keywords":["GPX4","Lipid peroxidation","Necroptosis","Programmed cell death","Phospholipid-hydroperoxide glutathione peroxidase","Biology","Cell biology","Apoptosis","Cell","Oxidative stress","Biochemistry","Glutathione peroxidase","Catalase","Cell death","QH301-705.5","Molecular biology","Lipids--Peroxidation","610","Lipoxygenases","Phospholipid Hydroperoxide Glutathione Peroxidase","Humans","Biology (General)","Cytology","Unsolved Mystery"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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