{"doi":"10.1364/ol.396023","title":"High-speed fiber-optic scanning nonlinear endomicroscopy for imaging neuron dynamics in vivo","abstract":"Fiber-optic-based two-photon fluorescence endomicroscopy is emerging as an enabling technology for in vivo histological imaging of internal organs and functional neuronal imaging on freely-behaving animals. However, high-speed imaging remains challenging due to the expense of miniaturization and lack of suited fast beam scanners. For many applications, a higher imaging speed is highly desired, especially for monitoring functional dynamics such as transient dendritic responses in neuroscience. This Letter reports the development of a fast fiber-optic scanning endo-microscope with an imaging speed higher than 26 frames/s. In vivo neural dynamics imaging with the high-speed endomicroscope was performed on a freely-behaving mouse over the primary motor cortex that expressed GCaMP6m. The results demonstrate its capability of real-time monitoring of transient neuronal dynamics with very fine temporal resolution.","journal":"Optics Letters","year":2020,"id":75243,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9568,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":392891,"name":"Honghua Guan","orcid":"0000-0002-4824-9185","position":1,"is_corresponding":false},{"id":392892,"name":"Ang Li","orcid":"0000-0001-7461-9437","position":2,"is_corresponding":false},{"id":392893,"name":"Yuanlei Yue","orcid":"0000-0002-0552-2911","position":3,"is_corresponding":false},{"id":392894,"name":"Ming-Jun Li","orcid":"0009-0008-8831-1191","position":4,"is_corresponding":false},{"id":392895,"name":"Hui Lü","orcid":"0000-0003-2336-2170","position":5,"is_corresponding":false},{"id":295612,"name":"Xingde Li","orcid":"0000-0002-4725-3297","position":6,"is_corresponding":false},{"id":394110,"name":"Hyeon‐Cheol Park","orcid":null,"position":0,"is_corresponding":true}],"reference_count":21,"raw_metadata":null,"created_at":"2026-07-18T21:46:33.313355Z","pmid":"32630910","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}