{"doi":"10.1364/boe.560539","title":"High-resolution multimodal visible light optical coherence tomography and scanning laser ophthalmoscopy for <i>in vivo</i> neuronal and vascular retinal imaging in mice","abstract":"Microglial cells play a crucial role in retinal vascular and brain diseases through complex interactions with blood vessels and neurons. To image retinal structures, vasculature, and microglia, we developed a multimodal system integrating visible light optical coherence tomography (vis-OCT) and scanning laser ophthalmoscopy (SLO). Both subsystems achieve micron-scale resolutions and operate within the diffraction limit across a 34-degree field of view: theoretically, the OCT system offers an axial resolution of 2.12 μm and a transverse resolution of 8.78 μm, while the SLO system provides a transverse resolution of 7.1 μm. We validated the system performance using transgenic mice with fluorescent protein-labeled microglia, revealing detailed retinal microstructures, microvasculature, and individual microglia with distinguishable branches, confirmed by ex vivo microscopy.","journal":"Biomedical Optics Express","year":2025,"id":541112,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9548,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":889675,"name":"Guangru B. Liang","orcid":"0000-0002-6322-3899","position":1,"is_corresponding":false},{"id":288601,"name":"Tristan T. Hormel","orcid":"0000-0002-7242-1934","position":2,"is_corresponding":false},{"id":295375,"name":"Yukun Guo","orcid":"0000-0002-6784-2355","position":3,"is_corresponding":false},{"id":305302,"name":"Min Gao","orcid":"0000-0002-0344-0162","position":4,"is_corresponding":false},{"id":360724,"name":"Benjamin Sivyer","orcid":"0000-0002-4537-5768","position":5,"is_corresponding":false},{"id":264208,"name":"J. Peter Campbell","orcid":"0000-0001-7964-9475","position":6,"is_corresponding":false},{"id":326975,"name":"Siyu Chen","orcid":"0000-0003-0336-3627","position":7,"is_corresponding":false},{"id":525574,"name":"Yifan Jian","orcid":"0000-0001-7988-7385","position":8,"is_corresponding":false},{"id":288604,"name":"Yali Jia","orcid":"0000-0002-2784-1905","position":9,"is_corresponding":false},{"id":1025500,"name":"Siyu Song","orcid":"0000-0001-9160-3111","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-19T02:52:42.901627Z","pmid":"40677383","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}