{"doi":"10.1364/boe.515469","title":"Next-generation endoscopic probe for detection of esophageal dysplasia using combined OCT and angle-resolved low-coherence interferometry","abstract":"Angle-resolved low-coherence interferometry (a/LCI) is an optical technique that enables depth-specific measurements of nuclear morphology, with applications to detecting epithelial cancers in various organs. Previous a/LCI setups have been limited by costly fiber-optic components and large footprints. Here, we present a novel a/LCI instrument incorporating a channel for optical coherence tomography (OCT) to provide real-time image guidance. We showcase the system's capabilities by acquiring imaging data from in vivo Barrett's esophagus patients. The main innovation in this geometry lies in implementing a pathlength-matched single-mode fiber array, offering substantial cost savings while preserving signal fidelity. A further innovation is the introduction of a specialized side-viewing probe tailored for esophageal imaging, featuring miniature optics housed in a custom 3D-printed enclosure attached to the tip of the endoscope. The integration of OCT guidance enhances the precision of tissue targeting by providing real-time morphology imaging. This novel device represents a significant advancement in clinical translation of an enhanced screening approach for esophageal precancer, paving the way for more effective early-stage detection and intervention strategies.","journal":"Biomedical Optics Express","year":2024,"id":434857,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9511,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":505336,"name":"Zachary A. Steelman","orcid":"0000-0003-4008-2111","position":1,"is_corresponding":false},{"id":1241619,"name":"Haoran Zhang","orcid":"0000-0003-4981-7065","position":2,"is_corresponding":false},{"id":505921,"name":"Kengyeh K. Chu","orcid":null,"position":3,"is_corresponding":false},{"id":402095,"name":"Cary C. Cotton","orcid":"0000-0002-0702-1336","position":4,"is_corresponding":false},{"id":502788,"name":"Swathi Eluri","orcid":"0000-0002-2839-1440","position":5,"is_corresponding":false},{"id":365133,"name":"Nicholas J. Shaheen","orcid":"0000-0001-6602-5647","position":6,"is_corresponding":false},{"id":505338,"name":"Adam Wax","orcid":"0000-0002-1827-5112","position":7,"is_corresponding":false},{"id":646045,"name":"Evan T. Jelly","orcid":"0000-0003-4678-9716","position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":null,"created_at":"2026-07-19T01:59:58.582186Z","pmid":"38495690","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}