{"doi":"10.1364/boe.499274","title":"Impaired cerebrovascular reactivity in pediatric sickle cell disease using diffuse correlation spectroscopy","abstract":"Cerebrovascular reactivity (CVR), defined as the ability of cerebral vasculature to dilate in response to a vasodilatory stimulus, is an integral mechanism in brain homeostasis that is thought to be impaired in sickle cell disease (SCD). This study used diffuse correlation spectroscopy and a simple breath-hold stimulus to quantify CVR non-invasively in a cohort of 12 children with SCD and 14 controls. Median [interquartile range] CVR was significantly decreased in SCD compared to controls (2.03 [1.31, 2.44] versus 3.49 [3.00, 4.11] %/mmHg, p = 0.028). These results suggest DCS may provide a feasible means to routinely monitor CVR impairments in pediatric SCD.","journal":"Biomedical Optics Express","year":2023,"id":377681,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.96,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1141697,"name":"Mariam Akbar","orcid":null,"position":1,"is_corresponding":false},{"id":1141698,"name":"Tisha Boodooram","orcid":null,"position":2,"is_corresponding":false},{"id":1141699,"name":"L. H. Harris","orcid":null,"position":3,"is_corresponding":false},{"id":376349,"name":"Shasha Bai","orcid":"0000-0003-4999-327X","position":4,"is_corresponding":false},{"id":780337,"name":"Rowan O. Brothers","orcid":"0000-0003-0587-4578","position":5,"is_corresponding":false},{"id":1141336,"name":"Michael Irvin Arrington","orcid":"0000-0003-0354-8509","position":6,"is_corresponding":false},{"id":416566,"name":"Seung Yup Lee","orcid":"0000-0002-0530-8464","position":7,"is_corresponding":false},{"id":1141700,"name":"Kirsma Khemani","orcid":null,"position":8,"is_corresponding":false},{"id":732888,"name":"Beatrice E. Gee","orcid":"0000-0003-0233-0321","position":9,"is_corresponding":false},{"id":416568,"name":"Erin M. Buckley","orcid":"0000-0003-1068-8411","position":10,"is_corresponding":false},{"id":781710,"name":"Kyle R. Cowdrick","orcid":"0000-0003-2236-6137","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-19T01:16:40.346877Z","pmid":"38021121","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}