{"doi":"10.1364/boe.395843","title":"Visible light optical coherence tomography angiography (vis-OCTA) facilitates local microvascular oximetry in the human retina","abstract":"We report herein the first visible light optical coherence tomography angiography (vis-OCTA) for human retinal imaging. Compared to the existing vis-OCT systems, we devised a spectrometer with a narrower bandwidth to increase the spectral power density for OCTA imaging, while retaining the major spectral contrast in the blood. We achieved a 100 kHz A-line rate, the fastest acquisition speed reported so far for human retinal vis-OCT. We rigorously optimized the imaging protocol such that a single acquisition took < 6 seconds with a field of view (FOV) of 3×7.8 mm 2 . The angiography enables accurate localization of microvasculature down to the capillary level and thus enables oximetry at vessels < 100 µm in diameter. We demonstrated microvascular hemoglobin oxygen saturation (sO 2 ) at the feeding and draining vessels at the perifoveal region. The longitudinal repeatability was assessed by < 5% coefficient of variation (CV). The unique capabilities of our vis-OCTA system may allow studies on the role of microvascular oxygen in various retinal pathologies.","journal":"Biomedical Optics Express","year":2020,"id":61172,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":58,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9563,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":323159,"name":"Wenjun Shao","orcid":"0000-0003-0945-882X","position":1,"is_corresponding":false},{"id":323160,"name":"Wei Yi","orcid":"0000-0003-4303-967X","position":2,"is_corresponding":false},{"id":323161,"name":"Rongrong Liu","orcid":"0000-0001-7853-7762","position":3,"is_corresponding":false},{"id":323162,"name":"Manishi Desai","orcid":"0000-0003-2391-6372","position":4,"is_corresponding":false},{"id":323163,"name":"Steven Ness","orcid":"0000-0002-5843-9476","position":5,"is_corresponding":false},{"id":323164,"name":"Ji Yi","orcid":"0000-0001-6583-7192","position":6,"is_corresponding":false},{"id":323158,"name":"Weiye Song","orcid":"0000-0002-1835-9770","position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-18T21:09:27.985420Z","pmid":"33014584","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}