{"doi":"10.1358/mf.2003.25.10.793325","title":"Upregulation of Fas and FasL expression in testosterone-induced\napoptosis of macrophages","abstract":null,"journal":"Methods and Findings in Experimental and Clinical Pharmacology","year":2003,"id":686905,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1794530,"name":"Zhu, Z.","orcid":null,"position":1,"is_corresponding":false},{"id":1794532,"name":"Liu, L.","orcid":null,"position":2,"is_corresponding":false},{"id":1794533,"name":"Guo, D.","orcid":null,"position":3,"is_corresponding":false},{"id":1794534,"name":"Jiang, T.","orcid":null,"position":4,"is_corresponding":false},{"id":1794535,"name":"Wang, L.","orcid":null,"position":5,"is_corresponding":false},{"id":1794536,"name":"Qiao, Z.","orcid":null,"position":6,"is_corresponding":false},{"id":1794529,"name":"Zhang, H.","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Upregulation of Fas and FasL expression in testosterone-induced\napoptosis of macrophages","abstract":"To the best of the authors' knowledge, there have been few reports on the effect of testosterone on the apoptosis of macrophages. In this report, we studied the effect of testosterone on the apoptosis of bone marrow-derived macrophages (BMMs) and the function of the Fas/Fas ligand (FasL) system in the process. Results showed that testosterone treatment in vitro at the physiological concentration of 10 nM did not induce the apoptosis of BMMs. However, BMMs underwent apoptosis when treated at higher concentrations of testosterone (100, 200 and 400 nM). Testosterone-induced apoptosis was associated with the enhanced expression of Fas, FasL, and caspase-8. These data suggest that the Fas/FasL system may play an important role in the testosterone-induced apoptosis of macrophages.","is_dataset_classified":null,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"14735224","pmcid":null,"openalex_id":"https://openalex.org/W2048834849","authors":[],"funders":[],"total_grants":0,"fwci":0.3393,"citation_percentile":0.6290219,"influential_citations":0,"citation_trend":[{"year":2014,"count":2},{"year":2020,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://doi.org/10.1358/mf.2003.25.10.793325","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/14735224","host_type":"repository"}],"fields_of_study":["Hormonal and reproductive studies","Tryptophan and brain disorders","Receptor Mechanisms and Signaling","Animals","Apoptosis","Blotting, Western","Bone Marrow Cells","Caspase 8","Caspases","Cell Line","Dose-Response Relationship, Drug","Fas Ligand Protein","Female","Macrophages","Membrane Glycoproteins","Mice","Mice, Inbred C57BL","Reverse Transcriptase Polymerase Chain Reaction","Testosterone","fas Receptor"],"mesh_terms":["Animals","Bone Marrow Cells","Cell Line","Dose-Response Relationship, Drug","Female","Macrophages","Membrane Glycoproteins","Mice, Inbred C57BL","Testosterone","Blotting, Western","Apoptosis","fas Receptor","Reverse Transcriptase Polymerase Chain Reaction","Caspases","Mice","Caspase 8","Fas Ligand Protein"],"keywords":["Fas ligand","Apoptosis","Testosterone (patch)","Downregulation and upregulation","In vitro","Chemistry","Macrophage","Endocrinology","Cancer research","Biology","Internal medicine","Cell biology","Programmed cell death","Medicine","Biochemistry","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T20:46:48.439956Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}