{"doi":"10.1358/dot.2012.48.9.1869590","title":"New and established tyrosine kinase inhibitors for chronic myeloid\nleukemia","abstract":null,"journal":"Drugs of Today","year":2012,"id":600344,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1539076,"name":"Green, K.","orcid":null,"position":1,"is_corresponding":false},{"id":1539078,"name":"Bowles, D.W.","orcid":null,"position":2,"is_corresponding":false},{"id":1539074,"name":"Thienelt, C.D.","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"New and established tyrosine kinase inhibitors for chronic myeloid\nleukemia","abstract":"Chronic myeloid leukemia (CML) is an uncommon malignancy, the treatment and prognosis of which have dramatically shifted over the last decade. Characterized by a translocation between chromosomes 9 and 22, known as the Philadelphia chromosome, small-molecule tyrosine kinase inhibitors (TKIs) targeted against the oncogenic BCR-ABL fusion protein have changed this once fatal disease into the model of targeted therapy. This article will review the pharmacological and clinical data supporting the use of imatinib and the second-generation TKIs dasatinib and nilotinib, and the novel TKIs bosutinib and ponatinib.","is_dataset_classified":null,"base_score":2.302585092994046,"endowment":2.302585092994046,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23032801","pmcid":null,"openalex_id":"https://openalex.org/W1554937972","authors":[],"funders":[],"total_grants":0,"fwci":1.3183,"citation_percentile":0.79578644,"influential_citations":0,"citation_trend":[{"year":2013,"count":6},{"year":2014,"count":2},{"year":2016,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://dx.doi.org/10.1358/dot.2012.48.9.1869590","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23032801","host_type":"repository"}],"fields_of_study":["Chronic Myeloid Leukemia Treatments","Chronic Lymphocytic Leukemia Research","Quinazolinone synthesis and applications","Aniline Compounds","Benzamides","Dasatinib","Humans","Imatinib Mesylate","Leukemia, Myelogenous, Chronic, BCR-ABL Positive","Nitriles","Piperazines","Protein Kinase Inhibitors","Protein-Tyrosine Kinases","Pyrimidines","Quinolines","Thiazoles"],"mesh_terms":["Imatinib Mesylate","Dasatinib","Aniline Compounds","Benzamides","Humans","Nitriles","Piperazines","Protein-Tyrosine Kinases","Pyrimidines","Quinolines","Thiazoles","Leukemia, Myelogenous, Chronic, BCR-ABL Positive","Protein Kinase Inhibitors"],"keywords":["Bosutinib","Nilotinib","Dasatinib","Medicine","Ponatinib","Myeloid leukemia","Imatinib","Tyrosine kinase","Cancer research","Homoharringtonine","Tyrosine-kinase inhibitor","Philadelphia chromosome","Imatinib mesylate","Druggability","Chromosomal translocation","Oncology","Internal medicine","Receptor","Biology","Cancer","Genetics"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T12:54:35.533616Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}