{"doi":"10.1302/0301-620x.97b11.35326","title":"Does pathological fracture affect the rate of local recurrence in patients with a giant cell tumour of bone?","abstract":"<jats:p> We investigated whether the presence of a pathological fracture increased the risk of local recurrence in patients with a giant cell tumour (GCT) of bone. We also assessed if curettage is still an appropriate form of treatment in the presence of a pathological fracture. We conducted a comprehensive review and meta-analysis of papers which reported outcomes in patients with a GCT with and without a pathological fracture at presentation. We computed the odds ratio (OR) of local recurrence in those with and without a pathological fracture. </jats:p><jats:p> We selected 19 eligible papers for final analysis. This included 3215 patients, of whom 580 (18.0%) had a pathological fracture. The pooled OR for local recurrence between patients with and without a pathological fracture was 1.05 (95% confidence interval (CI) 0.66 to 1.67, p = 0.854). Amongst the subgroup of patients who were treated with curettage, the pooled OR for local recurrence was 1.23 (95% CI 0.75 to 2.01, p = 0.417). </jats:p><jats:p> A post hoc sample size calculation showed adequate power for both comparisons. </jats:p><jats:p> There is no difference in local recurrence rates between patients who have a GCT of bone with and without a pathological fracture at the time of presentation. The presence of a pathological fracture should not preclude the decision to perform curettage as carefully selected patients who undergo curettage can have similar outcomes in terms of local recurrence to those without such a fracture. </jats:p><jats:p> Cite this article: Bone Joint J 2015;97-B:1566–71. </jats:p>","journal":"The Bone &amp; Joint Journal","year":2015,"id":39535,"datarank":3.3308822402751277,"base_score":3.6888794541139363,"endowment":3.6888794541139363,"self_citation_contribution":0.5533319181170905,"citation_network_contribution":2.7775503221580373,"self_endowment_contribution":0.5533319181170905,"citer_contribution":2.7775503221580373,"corpus_percentile":null,"corpus_rank":null,"citation_count":39,"citer_count":36,"citers_with_citation_signal":26,"citers_with_endowment":26,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":145139,"name":"Y. Chen","orcid":null,"position":1,"is_corresponding":false},{"id":8412,"name":"X. Chen","orcid":"0009-0000-5088-114X","position":2,"is_corresponding":false},{"id":193950,"name":"J. H. Tan","orcid":null,"position":3,"is_corresponding":false},{"id":46449,"name":"G. Singh","orcid":null,"position":4,"is_corresponding":false},{"id":193952,"name":"B. C. Tai","orcid":null,"position":5,"is_corresponding":false},{"id":193954,"name":"L. W. Khin","orcid":null,"position":6,"is_corresponding":false},{"id":193956,"name":"M. E. Puhaindran","orcid":null,"position":7,"is_corresponding":false},{"id":193948,"name":"A. A. Salunke","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.6888794541139363,"endowment":3.6888794541139363,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26530662","pmcid":null,"openalex_id":"https://openalex.org/W2267781735","authors":[],"funders":[],"total_grants":0,"fwci":2.8492,"citation_percentile":0.90090923,"influential_citations":2,"citation_trend":[{"year":2016,"count":3},{"year":2017,"count":4},{"year":2018,"count":4},{"year":2019,"count":4},{"year":2020,"count":3},{"year":2021,"count":7},{"year":2022,"count":5},{"year":2023,"count":1},{"year":2024,"count":2},{"year":2025,"count":2},{"year":2026,"count":2}],"oa_status":"closed","license":"https://online.boneandjoint.org.uk/TDM","oa_locations":[{"url":"https://online.boneandjoint.org.uk/doi/pdf/10.1302/0301-620X.97B11.35326","host_type":"publisher"},{"url":"https://online.boneandjoint.org.uk/doi/full-xml/10.1302/0301-620X.97B11.35326","host_type":"publisher"},{"url":"https://doi.org/10.1302/0301-620x.97b11.35326","host_type":"journal"}],"fields_of_study":["Bone Tumor Diagnosis and Treatments","Sarcoma Diagnosis and Treatment","Musculoskeletal synovial abnormalities and treatments","Medicine","Bone Neoplasms","Curettage","Fractures, Spontaneous","Giant Cell Tumor of Bone","Humans","Neoplasm Recurrence, Local","Prognosis","Risk Factors"],"mesh_terms":["Humans","Giant Cell Tumor of Bone","Bone Neoplasms","Neoplasm Recurrence, Local","Fractures, Spontaneous","Prognosis","Curettage","Risk Factors"],"keywords":["Pathological","Curettage","Medicine","Confidence interval","Odds ratio","Surgery","Stage (stratigraphy)","Radiology","Internal medicine","Adjuvant","Giant Cell Tumour","Local Recurrence","Pathologic Fracture","Wide Resection","Gct"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-11T20:47:29.896198Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}