{"doi":"10.1292/jvms.66.965","title":"Sequencing of Canine 5-Hydroxytriptamine Receptor (5-HTR) 1B, 2A, 2C Genes and Identification of Polymorphisms in the 5-HTR1B Gene","abstract":null,"journal":"Journal of Veterinary Medical Science","year":2004,"id":605075,"datarank":0.47670807455219194,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"self_citation_contribution":0.47670807455219194,"citation_network_contribution":0.0,"self_endowment_contribution":0.47670807455219194,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1552701,"name":"Chie HASHIZUME","orcid":null,"position":1,"is_corresponding":false},{"id":1552703,"name":"Niwako OGATA","orcid":null,"position":2,"is_corresponding":false},{"id":1552705,"name":"Takefumi KIKUSUI","orcid":null,"position":3,"is_corresponding":false},{"id":1552707,"name":"Yukari TAKEUCHI","orcid":null,"position":4,"is_corresponding":false},{"id":1552708,"name":"Yuji MORI","orcid":null,"position":5,"is_corresponding":false},{"id":1552698,"name":"Koji MASUDA","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Sequencing of Canine 5-Hydroxytriptamine Receptor (5-HTR) 1B, 2A, 2C Genes and Identification of Polymorphisms in the 5-HTR1B Gene","abstract":"Polymorphisms of human genes encoding 5-hydroxytriptamine (serotonin) receptors (5-HTRs) are thought to be associated with psychiatric disorders and behavioral traits. In the present study, we searched for corresponding polymorphisms in the dog and compared allelic frequencies for the canine 5-HTR1B, 5-HTR2A, and 5-HTR2C genes among five canine breeds. The canine genes consisted of the following: 5-HTR1B, 1170 bp; 5-HTR2A, 1413 bp; and 5-HTR2C, 1377 bp. All of these genes were highly homologous with the human genes. We found six single nucleotide polymorphisms (SNPs) in the 5-HTR1B gene (G57A, A157C, G246A, C660G, T955C, and G1146C). Genotyping of the respective SNPs revealed that there were inter-breed variations in the genotypes and allelic frequencies for four out of the six identified SNPs, suggesting that further analyses of the polymorphisms of the 5-HTR1B gene would be useful in order to gain an understanding of the genetic background underlying the diversified behavioral traits among canine species.","is_dataset_classified":null,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15353848","pmcid":null,"openalex_id":"https://openalex.org/W2049974637","authors":[],"funders":[],"total_grants":0,"fwci":1.6196,"citation_percentile":0.83393324,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2014,"count":1},{"year":2015,"count":3}],"oa_status":"hybrid","license":"cc-by-nc-nd","oa_locations":[{"url":"https://www.jstage.jst.go.jp/article/jvms/66/8/66_8_965/_pdf","host_type":"journal"},{"url":"https://www.jstage.jst.go.jp/article/jvms/66/8/66_8_965/_pdf","host_type":"publisher"},{"url":"https://doi.org/10.1292/jvms.66.965","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/15353848","host_type":"repository"}],"fields_of_study":["Human-Animal Interaction Studies","Neuroendocrine regulation and behavior","Neurotransmitter Receptor Influence on Behavior","Animals","Base Sequence","Behavior, Animal","Brain","DNA Primers","DNA, Complementary","Dogs","Gene Frequency","Genetic Carrier Screening","Genotype","Molecular Sequence Data","Polymorphism, Genetic","RNA, Messenger","Receptor, Serotonin, 5-HT1B","Sequence Analysis, DNA","Sequence Homology","Species Specificity"],"mesh_terms":["Animals","Base Sequence","Behavior, Animal","Brain","Dogs","Gene Frequency","Genotype","Genetic Carrier Screening","Molecular Sequence Data","Polymorphism, Genetic","RNA, Messenger","Species Specificity","Sequence Homology","Sequence Analysis, DNA","DNA Primers","DNA, Complementary","Receptor, Serotonin, 5-HT1B"],"keywords":["Single-nucleotide polymorphism","Gene","Genetics","Genotyping","Biology","Genotype","Allele","SNP genotyping","Polymorphism (computer science)","Candidate gene"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T01:35:39.806611Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}