{"doi":"10.1292/jvms.19-0446","title":"Neutralization of transforming growth factor (TGF)-β1 activity reduced          fibrosis and enhanced regeneration of glycerol-injured rat muscle","abstract":null,"journal":"Journal of Veterinary Medical Science","year":2020,"id":594617,"datarank":0.40620753016533157,"base_score":2.70805020110221,"endowment":2.70805020110221,"self_citation_contribution":0.40620753016533157,"citation_network_contribution":0.0,"self_endowment_contribution":0.40620753016533157,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1522263,"name":"Katsuhiko WARITA","orcid":null,"position":1,"is_corresponding":false},{"id":1522264,"name":"Yoshinao Z. HOSAKA","orcid":null,"position":2,"is_corresponding":false},{"id":1522262,"name":"Mohamed A. A. MAHDY","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Neutralization of transforming growth factor (TGF)-β1 activity reduced          fibrosis and enhanced regeneration of glycerol-injured rat muscle","abstract":"Recently, we have shown that glycerol induces early fibrosis in rat muscles which persists up to two weeks after injury. The current study aims to determine the possible factor associated with fibrosis of rat muscle following glycerol injury. Eight-week-old male Wistar rats received either glycerol only (as a control) or a co-treatment of neutralizing antibody to transforming growth factor (TGF)-β1 (5 and 12.5 µg). Both antibody doses significantly decreased fibrosis and improved muscle regeneration suggesting that anti-TGF-β1 antibody has both anti-fibrotic and myogenic effects. In conclusion, fibrosis developed in glycerol-injured rat muscles, might be mediated, in part, by the upregulation of TGF-β1 expression. Targeting TGF-β1 could be a promising approach for inhibiting fibrosis and enhancing muscle regeneration.","is_dataset_classified":null,"base_score":2.70805020110221,"endowment":2.70805020110221,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31875598","pmcid":"PMC7041973","openalex_id":"https://openalex.org/W2997808911","authors":[],"funders":[],"total_grants":0,"fwci":0.2277,"citation_percentile":0.52727646,"influential_citations":0,"citation_trend":[{"year":2021,"count":1},{"year":2022,"count":2},{"year":2023,"count":4},{"year":2024,"count":5},{"year":2025,"count":2}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://www.jstage.jst.go.jp/article/jvms/82/2/82_19-0446/_pdf","host_type":"journal"},{"url":"https://www.jstage.jst.go.jp/article/jvms/82/2/82_19-0446/_pdf","host_type":"publisher"},{"url":"https://doi.org/10.1292/jvms.19-0446","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31875598","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7041973","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC7041973","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC7041973?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Muscle Physiology and Disorders","Tendon Structure and Treatment","Sports injuries and prevention"],"mesh_terms":["Animals","Disease Models, Animal","Fibrosis","Glycerol","Injections, Intramuscular","Male","Muscular Diseases","Regeneration","Rats, Wistar","Muscle, Skeletal","Transforming Growth Factor beta1","Antibodies, Neutralizing"],"keywords":["Transforming growth factor","Fibrosis","Regeneration (biology)","Glycerol","Neutralizing antibody","Downregulation and upregulation","Endocrinology","Internal medicine","Growth factor","Antibody","Neutralization","Medicine","Chemistry","Immunology","Biology","Biochemistry","Cell biology","Receptor","Rat","Muscle Regeneration","Glycerol Injury","Anti-transforming Growth Factor-β1"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T15:02:49.957309Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}