{"doi":"10.1292/jvms.09-0458","title":"Muscarinic Receptor Subtypes Mediating Ca2+ Sensitization of Intestinal Smooth Muscle Contraction: Studies with Receptor Knockout Mice","abstract":null,"journal":"Journal of Veterinary Medical Science","year":2010,"id":590916,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1506140,"name":"Hayato MATSUYAMA","orcid":null,"position":1,"is_corresponding":false},{"id":1506142,"name":"Yasuyuki TANAHASHI","orcid":null,"position":2,"is_corresponding":false},{"id":1506143,"name":"Toshihiro UNNO","orcid":null,"position":3,"is_corresponding":false},{"id":1511865,"name":"Takio KITAZAWA","orcid":null,"position":4,"is_corresponding":false},{"id":1511866,"name":"Masahisa YAMADA","orcid":null,"position":5,"is_corresponding":false},{"id":1511867,"name":"Seiichi KOMORI","orcid":null,"position":6,"is_corresponding":false},{"id":1511862,"name":"Mayuko SUGURO","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Muscarinic Receptor Subtypes Mediating Ca2+ Sensitization of Intestinal Smooth Muscle Contraction: Studies with Receptor Knockout Mice","abstract":"In the present study, we have characterized muscarinic receptor subtypes that mediate carbachol-induced Ca2+ sensitization of contraction in intestinal smooth muscle, using mutant mice lacking M(2) or M(3) muscarinic receptors or both receptor subtypes. In alpha-toxin-permeabilized muscle strips from wild-type (WT) mice, isometric tension responses to Ca2+ applied cumulatively (pCa 7.0-5.0) were increased when the muscarinic agonist carbachol (100 microM) was added to the medium, as judged from shifts of pCa-tension curves in both 50% effective concentration (EC(50)) and maximum response (E(max)) of pCa-tension curve. In preparations from M(2)-knockout (KO) mice, pCa-tension curves were also shifted by carbachol (100 microM), and the extents of the EC(50) and E(max) changes resembled those observed in preparations from WT mice. In preparations from M(3)-KO or M(2)/M(3)-double KO mice, however, no significant changes in pCa-tension curves were obtained after carbachol application. The G(q/11)-type G-protein inhibitor YM-254890 (1 microM) completely blocked the Ca2+ sensitization of contraction induced by carbachol in M(2)-KO or WT preparations. The results strongly support the idea that the muscarinic activation of Ca2+ sensitization in intestinal smooth muscles is mediated by the M(3) muscarinic receptor coupled to G(q/11)-type G-proteins, without any significant involvement of the other muscarinic receptor subtypes including M(2).","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20009428","pmcid":null,"openalex_id":"https://openalex.org/W20009428","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.00300513,"influential_citations":0,"citation_trend":[],"oa_status":"hybrid","license":"cc-by-nc-nd","oa_locations":[{"url":"https://www.jstage.jst.go.jp/article/jvms/72/4/72_09-0458/_pdf","host_type":"publisher"},{"url":"http://www.jstage.jst.go.jp/article/jvms/72/4/72_09-0458/_pdf","host_type":"publisher"},{"url":"https://dialnet.unirioja.es/servlet/articulo?codigo=3023765","host_type":"journal"},{"url":"https://rakuno.repo.nii.ac.jp/records/3669","host_type":"repository"}],"fields_of_study":["Media and Digital Communication","Animals","Calcium","Carbachol","Female","Guanosine Triphosphate","Ileum","Intestines","Male","Mice","Mice, Knockout","Muscle Contraction","Muscle, Smooth","Peptides, Cyclic","Receptor, Muscarinic M2","Receptor, Muscarinic M3","Receptors, Muscarinic"],"mesh_terms":["Muscle, Smooth","Intestines","Ileum","Animals","Mice, Knockout","Mice","Calcium","Carbachol","Peptides, Cyclic","Receptors, Muscarinic","Receptor, Muscarinic M2","Receptor, Muscarinic M3","Guanosine Triphosphate","Muscle Contraction","Female","Male"],"keywords":["Political science"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-25T13:08:52.834302Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}