{"doi":"10.1289/isesisee.2018.o02.01.25","title":"Ethical Considerations Related to Studies of the Exposome","abstract":null,"journal":"ISEE Conference Abstracts","year":2018,"id":598884,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1534830,"name":"Susan M Pinney","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Ethical Considerations Related to Studies of the Exposome","abstract":"The exposome encompasses the totality of human environmental exposures from conception onwards, complementing the genome. The concept was first proposed in 2005 by Christopher Wild in an article entitled \"Complementing the genome with an ‘exposome’: the outstanding challenge of environmental exposure measurement in molecular epidemiology\". The idea of the exposome was first proposed during a time of great attention to the genome, and refocused attention on environmental exposure data for casual research. In studying the exposome, there are both technical and ethical challenges. What is the current state of research methods for studying the exposome? What is our level of precision in characterizing the exposome (beneficence – maximize possible benefits and minimize possible harms)? Have these methods been validated? Are there ways to assess whether statistical methods for studying exposure mixtures yield valid results? Do we have sufficient confidence in the methods to communicate the results to the general public (beneficence)? With very complex analytical methods, and considering multiple environmental and lifestyle risk factors simultaneously, how do we communicate risk to the general public (comprehension – present the information at the study subject’s level of understanding)? When returning individual exposure information (from environmental sampling or biomarkers), how many exposures are reasonable to include (respect for autonomy)? Among participants who were minor children at the time the data and biospecimens were collected and are now adults, should they be consented as adults before receiving individual exposure information? What level of responsibility does the environmental epidemiologist have to move research findings into public health action? And how?","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21097893","pmcid":null,"openalex_id":"https://openalex.org/W2939223383","authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://ehp.niehs.nih.gov/doi/10.1289/isesisee.2018.O02.01.25","host_type":"publisher"},{"url":"https://doi.org/10.1289/isesisee.2018.o02.01.25","host_type":"journal"}],"fields_of_study":["Health, Environment, Cognitive Aging","Delphi Technique in Research"],"mesh_terms":[],"keywords":["Exposome","Beneficence","Environmental epidemiology","Exposure assessment","Environmental health","Medicine","Autonomy","Political science"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T16:21:45.427580Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}