{"doi":"10.1289/ehp8495","title":"CATMoS: Collaborative Acute Toxicity Modeling Suite","abstract":"BACKGROUND: models built using existing data facilitate rapid acute toxicity predictions without using animals. OBJECTIVES: ). METHODS: An acute oral toxicity data inventory for 11,992 chemicals was compiled, split into training and evaluation sets, and made available to 35 participating international research groups that submitted a total of 139 predictive models. Predictions that fell within the applicability domains of the submitted models were evaluated using external validation sets. These were then combined into consensus models to leverage strengths of individual approaches. RESULTS: results. DISCUSSION: rat acute oral toxicity studies. CATMoS predictions for more than 800,000 chemicals have been made available via the National Toxicology Program's Integrated Chemical Environment tools and data sets (ice.ntp.niehs.nih.gov). 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