{"doi":"10.1289/ehp17057","title":"Bisphenol S Exposure and MASLD: A Mechanistic Study in Mice","abstract":"BACKGROUND: Bisphenol S (BPS) is a substitute for bisphenol A in various commercial products and is increasingly used globally due to restrictions on bisphenol A usage. Consequently, there are increasing public health concerns that substantial effects mediated by synthetic chemicals may impact human health. Recently, epidemiology studies reported associations between bisphenol exposure and nonalcoholic fatty liver disease [metabolic dysfunction-associated steatotic liver disease (MASLD)]. However, the causal relationship and the molecular mechanisms affecting hepatocellular functions are still unknown. OBJECTIVES: Our study aimed to understand the molecular mechanism by which BPS exposure caused hepatic lipid deposition. METHODS: C57BL/6J mice were exposed to BPS for 3 months, and its effects were assessed by histology. RNA sequencing (RNA-seq), assay for transposase-accessible chromatin with high-throughout sequencing (ATAC-seq), and cleavage under targets and tagmentation (CUT&Tag) were used to investigate mechanistic details. ATF3 liver-specific knockout mice and cells were used to validate its functions in BPS-induced hepatotoxicity. RESULTS: significantly attenuates BPS-induced hepatic lipid accumulation via the regulation of chromatin accessibility and gene expression. Besides, inhibiting JunB also eliminates BPS-induced Atf3 upregulation and lipid accumulation. CONCLUSION: Our study reveals a novel mechanism, through which BPS upregulates JunB and Atf3 to impair hepatic lipid metabolism, and provides new insights into the hepatotoxicity of BPS. https://doi.org/10.1289/EHP17057.","journal":"Environmental Health Perspectives","year":2025,"id":518207,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.964,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1385633,"name":"Yun Fan","orcid":"0000-0003-1755-0175","position":1,"is_corresponding":false},{"id":476855,"name":"Min Tang","orcid":"0000-0002-8350-5148","position":2,"is_corresponding":false},{"id":1385634,"name":"Xiaorong Wu","orcid":"0000-0002-1589-978X","position":3,"is_corresponding":false},{"id":1386112,"name":"Shengjun Bai","orcid":null,"position":4,"is_corresponding":false},{"id":1386113,"name":"Xiancheng Yang","orcid":null,"position":5,"is_corresponding":false},{"id":1310046,"name":"Xueer Zhang","orcid":null,"position":6,"is_corresponding":false},{"id":902903,"name":"Chuncheng Lu","orcid":"0000-0003-3689-9188","position":7,"is_corresponding":false},{"id":1385635,"name":"Chenbo Ji","orcid":"0000-0002-9869-4228","position":8,"is_corresponding":false},{"id":247177,"name":"Paul A. Wade","orcid":"0000-0002-6042-357X","position":9,"is_corresponding":false},{"id":1385636,"name":"Xu Wang","orcid":"0000-0001-9141-4206","position":10,"is_corresponding":false},{"id":1385637,"name":"Wei Gu","orcid":"0000-0003-4310-4072","position":11,"is_corresponding":false},{"id":1386114,"name":"Guizhen Du","orcid":null,"position":12,"is_corresponding":false},{"id":307410,"name":"Yufeng Qin","orcid":"0000-0002-3947-7610","position":13,"is_corresponding":false},{"id":1385632,"name":"Shiqi Li","orcid":"0000-0002-0902-6472","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-19T02:49:09.679930Z","pmid":"40203079","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}