{"doi":"10.1289/ehp10293","title":"Maternal Phthalate and Bisphenol Urine Concentrations during Pregnancy and Early Markers of Arterial Health in Children","abstract":null,"journal":"Environmental Health Perspectives","year":2022,"id":626054,"datarank":0.4887144807032224,"base_score":3.258096538021482,"endowment":3.258096538021482,"self_citation_contribution":0.4887144807032224,"citation_network_contribution":0.0,"self_endowment_contribution":0.4887144807032224,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":279628,"name":"Romy Gaillard","orcid":"0000-0002-7967-4600","position":1,"is_corresponding":false},{"id":279593,"name":"Susana Santos","orcid":"0000-0003-0613-3181","position":2,"is_corresponding":false},{"id":349340,"name":"Chalana M. Sol","orcid":null,"position":3,"is_corresponding":false},{"id":215952,"name":"Kurunthachalam Kannan","orcid":null,"position":4,"is_corresponding":false},{"id":23302,"name":"Leonardo Trasande","orcid":"0000-0002-1928-597X","position":5,"is_corresponding":false},{"id":444616,"name":"Vincent W.V. Jaddoe","orcid":null,"position":6,"is_corresponding":false},{"id":1172306,"name":"Sophia M. Blaauwendraad","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Maternal Phthalate and Bisphenol Urine Concentrations during Pregnancy and Early Markers of Arterial Health in Children","abstract":"<h4>Background</h4>Fetal exposure to endocrine-disrupting chemicals such as phthalates and bisphenols might lead to fetal cardiovascular developmental adaptations and predispose individuals to cardiovascular disease in later life.<h4>Objectives</h4>We examined the associations of maternal urinary bisphenol and phthalate concentrations in pregnancy with offspring carotid intima-media thickness and distensibility at the age of 10 y.<h4>Methods</h4>In a population-based, prospective cohort study of 935 mother-child pairs, we measured maternal urinary phthalate and bisphenol concentrations at each trimester. Later, we measured child carotid intima-media thickness and distensibility in the children at age 10 y using ultrasound.<h4>Results</h4>Maternal urinary average or trimester-specific phthalate concentrations were not associated with child carotid intima-media thickness at age 10 y. Higher maternal average concentrations of total bisphenol, especially bisphenol A, were associated with a lower carotid intima-media thickness [differences -0.15 standard deviation score and 95% confidence interval (CI): -0.24, -0.09 and -0.13 (95% CI: -0.22, -0.04) per interquartile range (IQR) increase in maternal urinary total bisphenol and bisphenol A concentration]. Trimester-specific analysis showed that higher maternal third-trimester total bisphenol and bisphenol A concentrations were associated with lower child carotid intima-media thickness [differences -0.13 (95% CI: -0.22, -0.04) and -0.13 (95% CI: -0.22, -0.05) per IQR increase in maternal urinary bisphenol concentration]. Maternal urinary bisphenol or phthalate concentrations were not associated with child carotid distensibility.<h4>Discussion</h4>In this large prospective cohort, higher maternal urinary bisphenols concentrations were associated with smaller childhood carotid intima-media thickness. Further studies are needed to replicate this association and to identify potential underlying mechanisms. https://doi.org/10.1289/EHP10293.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35471947","pmcid":"PMC9041527","openalex_id":null,"authors":[],"funders":[{"funder_name":"ZonMw","grant_id":"529051026","title":null},{"funder_name":"NIEHS NIH HHS","grant_id":"R01 ES029779","title":null},{"funder_name":"NIEHS NIH HHS","grant_id":"R01 ES022972","title":null},{"funder_name":"ZonMw","grant_id":"543003109","title":null},{"funder_name":"European Research Council","grant_id":"648916","title":"Embryonic origins of cardiovascular health in later life: disentangling early causal pathways in a lifecourse perspective"},{"funder_name":"National Institutes of Health","grant_id":"5R01ES029779-04","title":"Preconceptual Bisphenol and Phthalate Effects on Early Embryonic Development"},{"funder_name":"European Commission","grant_id":"874583","title":"Advancing Tools for Human Early Lifecourse Exposome Research and Translation"},{"funder_name":"European Commission","grant_id":"727565","title":"ERA-Net on INtesTInal MICrobiomics, diet and health, implementing JPI HDHL objectives"},{"funder_name":"National Institutes of Health","grant_id":"5R01ES022972-03","title":"Phthalates, BPA, Trajectories of In and Ex Utero Growth and Cardiometabolic Risks"}],"total_grants":9,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"public-domain","oa_locations":[{"url":"https://doi.org/10.1289/ehp10293","host_type":"publisher"},{"url":"https://ehp.niehs.nih.gov/doi/pdf/10.1289/EHP10293","host_type":"publisher"},{"url":"https://pure.eur.nl/en/publications/957cc860-81d1-43d6-a655-0d2b2bc7f820","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9041527","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9041527","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9041527?pdf=render","host_type":"Europe_PMC"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35471947","host_type":""},{"url":"http://dx.doi.org/10.1289/EHP10293","host_type":""},{"url":"https://doi.org/10.1289/EHP10293","host_type":""},{"url":"http://dx.doi.org/10.1289/ehp10293","host_type":""}],"fields_of_study":["01 natural sciences","03 medical and health sciences","0302 clinical medicine","0105 earth and related environmental sciences"],"mesh_terms":["Humans","Phthalic Acids","Benzhydryl Compounds","Phenols","Prospective Studies","Maternal Exposure","Pregnancy","Child","Female","Carotid Intima-Media Thickness","Biomarkers","Bisphenol A Compounds"],"keywords":["Research","Phthalic Acids","Carotid Intima-Media Thickness","SDG 3 - Good Health and Well-being","Phenols","Maternal Exposure","Pregnancy","Humans","Female","Bisphenol A Compounds","Prospective Studies","Benzhydryl Compounds","Child","Biomarkers"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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