{"doi":"10.1289/ehp.0901575","title":"Placental Transfer of Conjugated Bisphenol A and Subsequent Reactivation in the Rat Fetus","abstract":null,"journal":"Environmental Health Perspectives","year":2010,"id":624254,"datarank":0.8176557680348552,"base_score":5.4510384535657,"endowment":5.4510384535657,"self_citation_contribution":0.8176557680348552,"citation_network_contribution":0.0,"self_endowment_contribution":0.8176557680348552,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":232,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1613644,"name":"Hidetomo Iwano","orcid":null,"position":1,"is_corresponding":false},{"id":1613646,"name":"Risa Yanagisawa","orcid":null,"position":2,"is_corresponding":false},{"id":1613648,"name":"Nanako Koike","orcid":null,"position":3,"is_corresponding":false},{"id":1308171,"name":"Hiroki Inoue","orcid":"0000-0002-0977-1405","position":4,"is_corresponding":false},{"id":1613649,"name":"Hiroshi Yokota","orcid":null,"position":5,"is_corresponding":false},{"id":1261304,"name":"Miyu Nishikawa","orcid":"0000-0001-7958-1247","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Placental Transfer of Conjugated Bisphenol A and Subsequent Reactivation in the Rat Fetus","abstract":"BACKGROUND: Bisphenol A (BPA), a well-known endocrine disruptor, is highly glucuronidated in the liver, and the resultant BPA-glucuronide (BPA-GA) is excreted primarily into bile. However, in rodents, prenatal exposure to low doses of BPA can adversely affect the fetus, despite the efficient drug-metabolizing systems of the dams. The transport mechanisms of BPA from mother to fetus are unknown. OBJECTIVES: To test our hypothesis that BPA-GA-an inactive metabolite-is passed through the placenta to the fetus, where it affects the fetus after reactivation, we investigated the placental transfer of BPA-GA and reactivation to BPA in the fetus. METHODS: After performing uterine perfusion with BPA-GA in pregnant rats, we examined the expression and localization of the placental transporters for drug metabolites in the perfusate by reverse-transcriptase polymerase chain reaction and immunohistochemistry. We also investigated the deconjugation of BPA-GA in the fetus and examined uridine 5 -diphospho-glucuronosyltransferase (UGT) activity toward BPA and the expression of UGT isoforms in fetal liver. RESULTS: We detected BPA-GA and deconjugated BPA in the fetus and amniotic fluid after perfusion. In the trophoblast cells, organic anion-transporting polypeptide 4a1 (Oatp4a1) was localized on the apical membrane, and multidrug resistance-associated protein 1 (Mrp1) was localized to the basolateral membrane. We observed deconjugation of BPA-GA in the fetus; furthermore, we found the expression of UGT2B1, which metabolizes BPA, to be quite low in the fetus. CONCLUSIONS: These results demonstrate that BPA-GA is transferred into the fetus and deconjugated in the fetus because of its vulnerable drug-metabolizing system.","is_dataset_classified":null,"base_score":5.4510384535657,"endowment":5.4510384535657,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20382578","pmcid":null,"openalex_id":"https://openalex.org/W2056456647","authors":[],"funders":[],"total_grants":0,"fwci":9.9207,"citation_percentile":0.98907376,"influential_citations":0,"citation_trend":[{"year":2012,"count":16},{"year":2013,"count":12},{"year":2014,"count":8},{"year":2015,"count":18},{"year":2016,"count":20},{"year":2017,"count":13},{"year":2018,"count":10},{"year":2019,"count":11},{"year":2020,"count":19},{"year":2021,"count":22},{"year":2022,"count":13},{"year":2023,"count":13},{"year":2024,"count":24},{"year":2025,"count":14},{"year":2026,"count":3}],"oa_status":"gold","license":"public-domain","oa_locations":[{"url":"https://doi.org/10.1289/ehp.0901575","host_type":"journal"},{"url":"https://doi.org/10.1289/ehp.0901575","host_type":"publisher"},{"url":"https://ehp.niehs.nih.gov/doi/pdf/10.1289/ehp.0901575","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/20382578","host_type":"repository"},{"url":"https://rakuno.repo.nii.ac.jp/records/2370","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2944077","host_type":"repository"}],"fields_of_study":["Effects and risks of endocrine disrupting chemicals","Toxic Organic Pollutants Impact","Skin Protection and Aging","Amniotic Fluid","Animals","Benzhydryl Compounds","Chromatography, High Pressure Liquid","Female","Fetus","Glucuronides","Immunohistochemistry","Mass Spectrometry","Phenols","Placenta","Pregnancy","Rats","Rats, Sprague-Dawley","Reverse Transcriptase Polymerase Chain Reaction","Bisphenol A Compounds"],"mesh_terms":["Bisphenol A Compounds","Amniotic Fluid","Animals","Benzhydryl Compounds","Chromatography, High Pressure Liquid","Female","Fetus","Immunohistochemistry","Phenols","Placenta","Pregnancy","Mass Spectrometry","Rats, Sprague-Dawley","Reverse Transcriptase Polymerase Chain Reaction","Glucuronides","Rats"],"keywords":["Fetus","Placenta","Fetal membrane","Internal medicine","Endocrinology","Amniotic fluid","Endocrine disruptor","Metabolite","Chemistry","Multidrug resistance-associated protein 2","Biology","Pregnancy","Endocrine system","Biochemistry","Transporter","Medicine","Hormone","ATP-binding cassette transporter"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T03:12:32.406781Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}