{"doi":"10.12788/jhm.3529","title":"Antibiotic Regimens and Associated Outcomes in Children Hospitalized With Staphylococcal Scalded Skin Syndrome","abstract":"BACKGROUND: Controversy exists regarding the optimal antibiotic regimen for use in hospitalized children with staphylococcal scalded skin syndrome (SSSS). Various regimens may confer toxin suppression and/or additional coverage for methicillin-susceptible Staphylococcus aureus (MSSA) or methicillin-resistant S aureus (MRSA). OBJECTIVES: To describe antibiotic regimens in hospitalized children with SSSS and examine the association between antistaphylococcal antibiotic regimens and patient outcomes. DESIGN/METHODS: Retrospective cohort study of children hospitalized with SSSS using the Pediatric Health Information System database (2011-2016). Children who received clindamycin monotherapy, clindamycin plus MSSA coverage (eg, nafcillin), or clindamycin plus MRSA coverage (eg, vancomycin) were included. The primary outcome was hospital length of stay (LOS); secondary outcomes were treatment failure and cost. Generalized linear mixed-effects models were used to compare outcomes among antibiotic groups. RESULTS: Of 1,259 children included, 828 children received the most common antistaphylococcal antibiotic regimens: clindamycin monotherapy (47%), clindamycin plus MSSA coverage (33%), and clindamycin plus MRSA coverage (20%). Children receiving clindamycin plus MRSA coverage had higher illness severity (44%) compared with clindamycin monotherapy (28%) and clindamycin plus MSSA (32%) (P =.001). In adjusted analyses, LOS and treatment failure did not differ among the 3 regimens (P =.42 and P =.26, respectively). Cost was significantly lower for children receiving clindamycin monotherapy and highest in those receiving clindamycin plus MRSA coverage (mean, $4,839 vs $5,348, respectively; P <.001). CONCLUSIONS: In children with SSSS, the addition of MSSA or MRSA coverage to clindamycin monotherapy was associated with increased cost and no incremental difference in clinical outcomes.","journal":"Journal of Hospital Medicine","year":2021,"id":202142,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9617,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":479764,"name":"Matt Hall","orcid":"0000-0001-7778-5887","position":1,"is_corresponding":false},{"id":535493,"name":"Michelle A. Lopez","orcid":"0000-0002-6745-0212","position":2,"is_corresponding":false},{"id":513302,"name":"Andrea T. Cruz","orcid":"0000-0002-6153-8440","position":3,"is_corresponding":false},{"id":782195,"name":"Mary Ann Queen","orcid":null,"position":4,"is_corresponding":false},{"id":781664,"name":"Dana Foradori","orcid":"0000-0002-2355-647X","position":5,"is_corresponding":false},{"id":633298,"name":"Paul L. Aronson","orcid":null,"position":6,"is_corresponding":false},{"id":479763,"name":"Jessica L. Markham","orcid":"0000-0003-1616-7721","position":7,"is_corresponding":false},{"id":782196,"name":"Jennifer A. Nead","orcid":null,"position":8,"is_corresponding":false},{"id":782197,"name":"Gabrielle Hester","orcid":null,"position":9,"is_corresponding":false},{"id":420535,"name":"Russell J. McCulloh","orcid":"0000-0002-0403-6639","position":10,"is_corresponding":false},{"id":781665,"name":"Sowdhamini S. Wallace","orcid":"0000-0002-6138-5923","position":11,"is_corresponding":false},{"id":782194,"name":"Hannah C. Neubauer","orcid":null,"position":0,"is_corresponding":true}],"reference_count":28,"raw_metadata":null,"created_at":"2026-07-18T23:51:05.955461Z","pmid":"33617441","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}