{"doi":"10.12688/f1000research.12684.1","title":"Radial glial cells in the adult dentate gyrus: what are they and where do they come from?","abstract":"<ns4:p>Adult neurogenesis occurs in the dentate gyrus in the mammalian hippocampus. These new neurons arise from neural precursor cells named radial glia-like cells, which are situated in the subgranular zone of the dentate gyrus. Here, we review the emerging topic of precursor heterogeneity in the adult subgranular zone. We also discuss how this heterogeneity may be established during development and focus on the embryonic origin of the dentate gyrus and radial glia-like stem cells. Finally, we discuss recently developed single-cell techniques, which we believe will be critical to comprehensively investigate adult neural stem cell origin and heterogeneity.</ns4:p>","journal":"F1000Research","year":2018,"id":41830,"datarank":2.278877804965518,"base_score":4.418840607796598,"endowment":4.418840607796598,"self_citation_contribution":0.6628260911694899,"citation_network_contribution":1.616051713796028,"self_endowment_contribution":0.6628260911694899,"citer_contribution":1.616051713796028,"corpus_percentile":null,"corpus_rank":null,"citation_count":82,"citer_count":78,"citers_with_citation_signal":68,"citers_with_endowment":68,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":201008,"name":"Allison M. 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Berg","orcid":"0000-0001-9595-2052","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.418840607796598,"endowment":4.418840607796598,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29568500","pmcid":"PMC5840617","openalex_id":"https://openalex.org/W2794183473","authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"R35NS097370","title":null},{"funder_name":"National Institutes of Health","grant_id":"R37NS047344","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"U19 MH106434","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"P01 NS097206","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"U19 AI131130","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"R01 MH105128","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG057497","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R35NS097370-03","title":"Functional roles of genetic risk factors for brain disorders in neurogenesis and neurodevelopment"},{"funder_name":"National Institutes of Health","grant_id":"1P01NS097206-01","title":"Epigenetic regulation of neurogenesis"},{"funder_name":"National Institutes of Health","grant_id":"1R21NS106434-01","title":"Dynamic Contributions of Identified Neurons to High Frequency Oscillations"},{"funder_name":"National Institutes of Health","grant_id":"1R01MH105128-01A1","title":"Circuitry mechanisms underlying normal and aberrant adult hippocampal neurogenesis"},{"funder_name":"National Institutes of Health","grant_id":"5U19AI131130-04","title":"Engineering a human brain organoid-based platform to study neurotropic viruses"},{"funder_name":"National Institutes of Health","grant_id":"1U19MH106434-01A1","title":"iPSC-based platform development for major psychiatric disorder modeling and discovery"},{"funder_name":"National Institutes of Health","grant_id":"2R37NS047344-10A1","title":"Local circuitry mechanisms regulating adult hippocampal neurogenesis"},{"funder_name":"National Institutes of Health","grant_id":"5R35NS097370-06","title":"Functional roles of genetic risk factors for brain disorders in neurogenesis and neurodevelopment"},{"funder_name":"National Institutes of Health","grant_id":"5R01AG057497-04","title":"Functional characterization of Alzheimer's disease associated genetic variants"}],"total_grants":16,"fwci":5.6065,"citation_percentile":0.97154073,"influential_citations":4,"citation_trend":[{"year":2018,"count":7},{"year":2019,"count":14},{"year":2020,"count":15},{"year":2021,"count":9},{"year":2022,"count":11},{"year":2023,"count":9},{"year":2024,"count":8},{"year":2025,"count":8},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://f1000research.com/articles/7-277/v1/pdf","host_type":"journal"},{"url":"https://f1000research.com/articles/7-277/v1/pdf","host_type":"GOLD"},{"url":"https://f1000research.com/articles/7-277/v1/pdf","host_type":"publisher"},{"url":"https://f1000research.com/articles/7-277/v1/xml","host_type":"publisher"},{"url":"https://f1000research.com/articles/7-277/v1/iparadigms","host_type":"publisher"},{"url":"https://doi.org/10.12688/f1000research.12684.1","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29568500","host_type":"repository"},{"url":"http://www.scopus.com/inward/record.url?scp=85043712968&partnerID=8YFLogxK","host_type":"repository"},{"url":"https://doaj.org/article/06f1a21bede142808ecc20e8bb1f8c13","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5840617","host_type":"repository"},{"url":"https://hdl.handle.net/2164/14625","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC5840617","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC5840617?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.12688/f1000research.12684.1","host_type":""},{"url":"https://dx.doi.org/10.12688/f1000research.12684.1","host_type":""},{"url":"https://doi.org/https://doi.org/10.12688/f1000research.12684.1","host_type":""}],"fields_of_study":["Neurogenesis and neuroplasticity mechanisms","Advanced Neuroimaging Techniques and Applications","Glioma Diagnosis and Treatment","Biology","Medicine","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":[],"keywords":["Dentate gyrus","Neuroscience","Open peer review","Plant biology","Biology","Medicine","Physiology","Hippocampus","Botany","Radial Glial Cells","Stem Cell Heterogeneity","Pharmacology","General Immunology and Microbiology","General Biochemistry,Genetics and Molecular Biology","610","QR Microbiology","Review","QR","Toxicology and Pharmaceutics(all)"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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