{"doi":"10.12688/f1000research.124891.1","title":"Higher amyloid correlates to greater loneliness during the COVID-19 pandemic","abstract":"<ns3:p> <ns3:bold>Background:</ns3:bold> Little is known about psychosocial characteristics, including loneliness, anxiety, and depression, present in preclinical Alzheimer disease (AD). The purpose of this cross-sectional study was to examine the relationship between these psychosocial characteristics and amyloid accumulation in cognitively normal older adults with and without preclinical AD during the COVID-19 pandemic. <ns3:bold>Methods:</ns3:bold> A global Clinical Dementia Rating <ns3:sup> <ns3:sup>®</ns3:sup> </ns3:sup> Scale score of 0 was required for enrollment. Cortical amyloid burden was measured using [11C] Pittsburgh compound B or [18F]-Florbetapir PET tracers. Centiloids were used to synchronize measures. Demographic characteristics and measures of loneliness, anxiety, and depression were collected via self-report. Spearman’s correlation was used to examine relationships between amyloid and psychosocial characteristics. <ns3:bold>Results:</ns3:bold> The 108 participants had a mean age of 75.0 and an average amyloid burden of 22.2. Higher amyloid accumulation was significantly associated with greater loneliness. <ns3:bold>Conclusions:</ns3:bold> Additional research is needed with a larger, more diverse sample to examine these psychosocial characteristics in preclinical AD. </ns3:p>","journal":"F1000Research","year":2022,"id":292674,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9589,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":442337,"name":"Rebecca M. Bollinger","orcid":"0000-0002-1931-8372","position":1,"is_corresponding":false},{"id":976749,"name":"Szu‐Wei Chen","orcid":"0000-0002-9630-0934","position":2,"is_corresponding":false},{"id":545478,"name":"Audrey A. Keleman","orcid":"0000-0003-1025-3100","position":3,"is_corresponding":false},{"id":727507,"name":"Regina Thompson","orcid":"0000-0003-4176-2581","position":4,"is_corresponding":false},{"id":27591,"name":"Anne M. Fagan","orcid":"0000-0002-5383-0214","position":5,"is_corresponding":false},{"id":226074,"name":"Beau M. Ances","orcid":"0000-0003-3862-7397","position":6,"is_corresponding":false},{"id":442340,"name":"Susan Stark","orcid":"0000-0002-2816-7158","position":7,"is_corresponding":false},{"id":976748,"name":"Abigail Kehrer-Dunlap","orcid":"0000-0001-6569-0960","position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:30:46.209549Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}