{"doi":"10.12688/f1000research.109644.2","title":"Mitochondrial haplogroup association with fasting glucose response in African Americans treated with a thiazide diuretic","abstract":"<ns4:p> <ns4:bold>Background:</ns4:bold> Hypertensive African Americans have a ~50% response rate to thiazide diuretic treatment. This contributes to a high prevalence of uncontrolled high blood pressure. Here, we examined the role of the mitochondrial genome on thiazide diuretic treatment response in hypertensive African Americans enrolled in a clinical trial. </ns4:p> <ns4:p> <ns4:bold>Methods:</ns4:bold> Participants from the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT, <ns4:italic/> n= 4279) were genotyped using the Illumina Infinium Multi-Ethnic Beadchip. Haplotype groups were called using HaploGrep. We used a linear regression analysis to examine the association between mitochondrial haplogroups (L, M, and N) and changes in blood pressure and fasting glucose over six months and two years, respectively. </ns4:p> <ns4:p> <ns4:bold>Results:</ns4:bold> The analysis revealed a null association between mitochondrial haplogroups M and N versus L for each of the outcomes. In subgroup analysis, the L subclades L1, L2, and L3/L4 (versus L0) were each inversely associated with fasting glucose response (p &lt; 0.05). </ns4:p> <ns4:p> <ns4:bold>Conclusions:</ns4:bold> This discovery analysis suggests the mitochondrial genome has a small effect on fasting glucose response, but not that of blood pressure, to thiazide diuretic treatment in African Americans. </ns4:p>","journal":"F1000Research","year":2022,"id":310880,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9511,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":686090,"name":"Nicole D. Armstrong","orcid":"0000-0002-6483-4560","position":1,"is_corresponding":false},{"id":708126,"name":"Vinodh Srinivasasainagendra","orcid":null,"position":2,"is_corresponding":false},{"id":25027,"name":"Hemant K. Tiwari","orcid":null,"position":3,"is_corresponding":false},{"id":488542,"name":"Scott W. Ballinger","orcid":"0000-0003-0300-9820","position":4,"is_corresponding":false},{"id":13351,"name":"Zechen Chong","orcid":"0000-0001-5750-1808","position":5,"is_corresponding":false},{"id":562947,"name":"Stella Aslibekyan","orcid":"0000-0003-1301-1844","position":6,"is_corresponding":false},{"id":24678,"name":"Donna K. Arnett","orcid":"0000-0003-2219-657X","position":7,"is_corresponding":false},{"id":24975,"name":"Marguerite R. Irvin","orcid":"0000-0002-1442-2023","position":8,"is_corresponding":false},{"id":831018,"name":"Bré Minniefield","orcid":"0000-0002-3008-6664","position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:33:24.451129Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}