{"doi":"10.12659/msm.893890","title":"Association between Four MMP-9 Polymorphisms and Breast Cancer Risk: A Meta-Analysis","abstract":null,"journal":"Medical Science Monitor","year":2015,"id":636154,"datarank":0.5050943744979712,"base_score":3.367295829986474,"endowment":3.367295829986474,"self_citation_contribution":0.5050943744979712,"citation_network_contribution":0.0,"self_endowment_contribution":0.5050943744979712,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1650858,"name":"Linxi Zhang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Association between Four MMP-9 Polymorphisms and Breast Cancer Risk: A Meta-Analysis","abstract":"BACKGROUND: The role of matrix metalloproteinase 9 (MMP-9) polymorphisms in breast cancer risk remains unclear. The purpose of this study was to evaluate the association between MMP-9 variants and breast cancer susceptibility. MATERIAL AND METHODS: Case-control studies were searched on electronic databases to retrieve related articles published between 2000 and 2014 concerning the role of MMP-9 variants in breast cancer risk. Pooled odds ratios (OR) with correlative 95% confidence intervals (CI) were employed to assess this association. RESULTS: Ten articles were screened out, including 6177 breast cancer patients and 6726 matched-controls. For rs3918242 (-1562 C/T), 6 studies contained 1435 patients and 1446 controls. Although the frequency of risk allele C was higher in breast cancer patients than in controls, only TT genotype in recessive model was significantly associated with increased risk of breast cancer (TT vs. CT+CC: OR=1.55, 95% CI=1.12-2.16, P=0.009) in a fixed-effects model. This significant relationship was not observed in other genetic models (P>0.05). No significant association was found between breast cancer risk and rs17576, rs2250889, and rs3787268 under any genetic models. CONCLUSIONS: Our results show that TT genotype of MMP-9-1562 C/T polymorphism might be a risk factor for breast cancer. More studies are needed to further explore this association.","is_dataset_classified":null,"base_score":3.367295829986474,"endowment":3.367295829986474,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25890491","pmcid":"PMC4413812","openalex_id":"https://openalex.org/W2032808049","authors":[],"funders":[],"total_grants":0,"fwci":0.4758,"citation_percentile":0.51239669,"influential_citations":0,"citation_trend":[{"year":2015,"count":2},{"year":2016,"count":2},{"year":2018,"count":2},{"year":2020,"count":5},{"year":2021,"count":1},{"year":2022,"count":5},{"year":2023,"count":4},{"year":2024,"count":5},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"hybrid","license":"cc-by-nc-nd","oa_locations":[{"url":"https://medscimonit.com/download/index/idArt/893890","host_type":"journal"},{"url":"https://medscimonit.com/download/index/idArt/893890","host_type":"publisher"},{"url":"http://www.medscimonit.com/download/index/idArt/893890","host_type":"publisher"},{"url":"https://doi.org/10.12659/msm.893890","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25890491","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4413812","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC4413812","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC4413812?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Protease and Inhibitor Mechanisms","HER2/EGFR in Cancer Research","Blood Coagulation and Thrombosis Mechanisms","Alleles","Breast Neoplasms","Female","Genes, Dominant","Genes, Recessive","Genetic Association Studies","Genetic Predisposition to Disease","Homozygote","Humans","Matrix Metalloproteinase 9","Models, Genetic","Polymorphism, Single Nucleotide","Publication Bias","Risk Factors"],"mesh_terms":["Alleles","Breast Neoplasms","Female","Genes, Dominant","Genes, Recessive","Homozygote","Humans","Models, Genetic","Risk Factors","Publication Bias","Genetic Predisposition to Disease","Polymorphism, Single Nucleotide","Matrix Metalloproteinase 9","Genetic Association Studies"],"keywords":["Meta-analysis","Breast cancer","Oncology","Medicine","Internal medicine","Matrix metalloproteinase","Cancer","Bioinformatics","Biology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"refsnp"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T16:25:17.011275Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}