{"doi":"10.1261/rna.2231506","title":"Interacting endogenous and exogenous RNAi pathways in\n                    <i>Caenorhabditis elegans</i>","abstract":"<jats:p>\n                    <jats:italic>C. elegans</jats:italic>\n                    contains numerous small RNAs of ~21–24 nt in length. The microRNAs (miRNAs) are small noncoding RNAs produced by DCR-1- and ALG-dependent processing of self-complementary hairpin transcripts. Endogenous small interfering RNAs (endo-siRNAs), associated with ongoing silencing of protein-coding genes in normal worms, are produced by mechanisms that involve DCR-1 but, unlike miRNAs, also involve RDE-2, RDE-3, RDE-4, RRF-1, and RRF-3. The tiny noncoding (tncRNAs) are similar to endo-siRNAs in their biogenesis except that they are derived from noncoding sequences. These endo-siRNA- and tncRNA-based endogenous RNAi pathways involve some components, including DCR-1 and RDE-4, that are shared with exogenous RNAi, and some components, including RRF-3 and ERI-1, that are specific to endogenous RNAi.\n                    <jats:italic>rrf-3</jats:italic>\n                    and\n                    <jats:italic>eri-1</jats:italic>\n                    mutants are enhanced for some silencing processes and defective for others, suggesting cross-regulatory interactions between RNAi pathways in\n                    <jats:italic>C. elegans</jats:italic>\n                    . Microarray expression profiling of RNAi-defective mutant worms further suggests diverse endogenous RNAi pathways for silencing different sets of genes.\n                  </jats:p>","journal":"RNA","year":2006,"id":674817,"datarank":0.8027787200214102,"base_score":5.351858133476067,"endowment":5.351858133476067,"self_citation_contribution":0.8027787200214102,"citation_network_contribution":0.0,"self_endowment_contribution":0.8027787200214102,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":210,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1763135,"name":"CHRISTOPHER M. HAMMELL","orcid":null,"position":1,"is_corresponding":false},{"id":1763136,"name":"VICTOR AMBROS","orcid":null,"position":2,"is_corresponding":false},{"id":1763134,"name":"ROSALIND C. LEE","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Interacting endogenous and exogenous RNAi pathways in\n                    <i>Caenorhabditis elegans</i>","abstract":"<jats:p>\n                    <jats:italic>C. elegans</jats:italic>\n                    contains numerous small RNAs of ~21–24 nt in length. The microRNAs (miRNAs) are small noncoding RNAs produced by DCR-1- and ALG-dependent processing of self-complementary hairpin transcripts. Endogenous small interfering RNAs (endo-siRNAs), associated with ongoing silencing of protein-coding genes in normal worms, are produced by mechanisms that involve DCR-1 but, unlike miRNAs, also involve RDE-2, RDE-3, RDE-4, RRF-1, and RRF-3. The tiny noncoding (tncRNAs) are similar to endo-siRNAs in their biogenesis except that they are derived from noncoding sequences. These endo-siRNA- and tncRNA-based endogenous RNAi pathways involve some components, including DCR-1 and RDE-4, that are shared with exogenous RNAi, and some components, including RRF-3 and ERI-1, that are specific to endogenous RNAi.\n                    <jats:italic>rrf-3</jats:italic>\n                    and\n                    <jats:italic>eri-1</jats:italic>\n                    mutants are enhanced for some silencing processes and defective for others, suggesting cross-regulatory interactions between RNAi pathways in\n                    <jats:italic>C. elegans</jats:italic>\n                    . Microarray expression profiling of RNAi-defective mutant worms further suggests diverse endogenous RNAi pathways for silencing different sets of genes.\n                  </jats:p>","is_dataset_classified":null,"base_score":5.351858133476067,"endowment":5.351858133476067,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16489184","pmcid":"PMC1421084","openalex_id":"https://openalex.org/W2124774982","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"F32GM69186-1","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"F32 GM069186","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM034028","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"GM34028","title":null}],"total_grants":4,"fwci":7.886,"citation_percentile":0.98362734,"influential_citations":0,"citation_trend":[{"year":2012,"count":11},{"year":2013,"count":13},{"year":2014,"count":10},{"year":2015,"count":6},{"year":2016,"count":7},{"year":2017,"count":5},{"year":2018,"count":11},{"year":2019,"count":6},{"year":2020,"count":6},{"year":2021,"count":7},{"year":2022,"count":4},{"year":2023,"count":5},{"year":2024,"count":16},{"year":2025,"count":8},{"year":2026,"count":1}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"http://rnajournal.cshlp.org/content/12/4/589.full.pdf","host_type":"journal"},{"url":"http://rnajournal.cshlp.org/content/12/4/589.full.pdf","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1261/rna.2231506","host_type":"publisher"},{"url":"https://doi.org/10.1261/rna.2231506","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16489184","host_type":"repository"},{"url":"https://repository.cshl.edu/id/eprint/27741/1/Hammell%20RNA%202006.pdf","host_type":"repository"},{"url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.669.9931","host_type":""},{"url":"http://rnajournal.cshlp.org/cgi/content/short/12/4/589","host_type":"repository"},{"url":"http://doi.org/10.1261/rna.2231506","host_type":"repository"}],"fields_of_study":["CRISPR and Genetic Engineering","RNA Research and Splicing","Genetics, Aging, and Longevity in Model Organisms"],"mesh_terms":["Animals","Base Sequence","Mutation","Blotting, Northern","Oligonucleotide Probes","Caenorhabditis elegans","Gene Silencing","RNA Interference"],"keywords":["RNA interference","Biology","Caenorhabditis elegans","Gene silencing","microRNA","Endogeny","Small interfering RNA","Cell biology","Piwi-interacting RNA","Mutant","Argonaute","Gene","RNA silencing","Genetics","RNA","Biochemistry"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T18:17:57.158072Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}