{"doi":"10.1261/rna.080442.125","title":"The m<sup>6</sup>A-binding protein YTHDF3 modulates the cardiac response to stress","abstract":"Transcriptional regulation of gene expression has long been studied; however, only recently has the impact of chemical mRNA modification on protein synthesis emerged. Among posttranscriptional modifications, methylation of the N 6 -adenosine site of mRNA (m 6 A) is very prevalent in eukaryotes and plays a critical role in the heart. To date, the mechanism through which m 6 A controls cardiac function remains elusive. The fate of m 6 A-modified mRNAs is regulated by members of the YTH domain family (YTHDF), such as YTHDF3. Here we report that mice with a cardiomyocyte-specific deletion of YTHDF3 have attenuated pathological remodeling following pressure overload injury. Mechanistically, we found that YTHDF3 regulates global stress-induced protein synthesis, and that this protein controls cardiomyocyte size. Altogether, this study uncovered a potential cardioprotective role for YTHDF3 inhibition and improves our understanding on the mechanism through which m 6 A impacts cardiac function.","journal":"RNA","year":2025,"id":531319,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9547,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1064712,"name":"Anindhya Sundar Das","orcid":"0000-0001-8651-4632","position":1,"is_corresponding":false},{"id":1228493,"name":"Volha A. Golubeva","orcid":"0000-0001-5430-3507","position":2,"is_corresponding":false},{"id":334329,"name":"Jop H. van Berlo","orcid":"0000-0001-9229-4429","position":3,"is_corresponding":false},{"id":303901,"name":"Federica Accornero","orcid":"0000-0003-1209-7228","position":4,"is_corresponding":false},{"id":537928,"name":"Charles P. Rabolli","orcid":"0000-0002-4383-8706","position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":null,"created_at":"2026-07-19T02:51:14.579161Z","pmid":"40216557","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}