{"doi":"10.1261/rna.078576.120","title":"The kinesin KIF1C transports APC-dependent mRNAs to cell protrusions","abstract":"RNA localization and local translation are important for numerous cellular functions. In mammals, a class of mRNAs localize to cytoplasmic protrusions in an APC-dependent manner, with roles during cell migration. Here, we investigated this localization mechanism. We found that the KIF1C motor interacts with APC-dependent mRNAs and is required for their localization. Live cell imaging revealed rapid, active transport of single mRNAs over long distances that requires both microtubules and KIF1C. Two-color imaging directly revealed single mRNAs transported by single KIF1C motors, with the 3'UTR being sufficient to trigger KIF1C-dependent RNA transport and localization. Moreover, KIF1C remained associated with peripheral, multimeric RNA clusters and was required for their formation. These results reveal a widespread RNA transport pathway in mammalian cells, in which the KIF1C motor has a dual role in transporting RNAs and clustering them within cytoplasmic protrusions. Interestingly, KIF1C also transports its own mRNA, suggesting a possible feedback loop acting at the level of mRNA transport.","journal":"RNA","year":2021,"id":162149,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":50,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9518,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":317882,"name":"Konstadinos Moissoglu","orcid":"0000-0001-7211-4320","position":1,"is_corresponding":false},{"id":562546,"name":"Emeline Coleno","orcid":null,"position":2,"is_corresponding":false},{"id":317881,"name":"Tianhong Wang","orcid":"0000-0002-0331-3761","position":3,"is_corresponding":false},{"id":562547,"name":"Arthur Imbert","orcid":null,"position":4,"is_corresponding":false},{"id":678432,"name":"Marie-Cécile Robert","orcid":"0000-0003-1603-4187","position":5,"is_corresponding":false},{"id":561980,"name":"Marion Peter","orcid":"0000-0002-5720-4798","position":6,"is_corresponding":false},{"id":562548,"name":"Racha Chouaib","orcid":null,"position":7,"is_corresponding":false},{"id":561981,"name":"Thomas Walter","orcid":"0000-0001-7419-7879","position":8,"is_corresponding":false},{"id":277668,"name":"Florian Mueller","orcid":"0000-0002-9622-4396","position":9,"is_corresponding":false},{"id":561982,"name":"Kazem Zibara","orcid":"0000-0002-9887-072X","position":10,"is_corresponding":false},{"id":558678,"name":"Édouard Bertrand","orcid":"0000-0002-9642-7994","position":11,"is_corresponding":false},{"id":317887,"name":"Stavroula Mili","orcid":"0000-0002-9161-8660","position":12,"is_corresponding":false},{"id":561979,"name":"Xavier Pichon","orcid":"0000-0002-0755-2305","position":0,"is_corresponding":true}],"reference_count":66,"raw_metadata":null,"created_at":"2026-07-18T23:45:00.600065Z","pmid":"34493599","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}