{"doi":"10.1261/rna.073502.119","title":"YTHDF2 destabilizes m<sup>6</sup>A-modified neural-specific RNAs to restrain differentiation in induced pluripotent stem cells","abstract":"N 6 -methyladenosine (m 6 A) is an abundant post-transcriptional modification that can impact RNA fate via interactions with m 6 A-specific RNA binding proteins. Despite accumulating evidence that m 6 A plays an important role in modulating pluripotency, the influence of m 6 A reader proteins in pluripotency is less clear. Here, we report that YTHDF2, an m 6 A reader associated with mRNA degradation, is highly expressed in induced pluripotent stem cells (iPSCs) and down-regulated during neural differentiation. Through RNA sequencing, we identified a group of m 6 A-modified transcripts associated with neural development that are directly regulated by YTDHF2. Depletion of YTHDF2 in iPSCs leads to stabilization of these transcripts, loss of pluripotency, and induction of neural-specific gene expression. Collectively, our results suggest YTHDF2 functions to restrain expression of neural-specific mRNAs in iPSCs and facilitate their rapid and coordinated up-regulation during neural induction. These effects are both achieved by destabilization of the targeted transcripts.","journal":"RNA","year":2020,"id":65745,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":55,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.951,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":349503,"name":"Joseph Russo","orcid":null,"position":1,"is_corresponding":false},{"id":348065,"name":"Jeffrey Wilusz","orcid":"0000-0001-8535-3435","position":2,"is_corresponding":false},{"id":30210,"name":"Erin Osborne Nishimura","orcid":"0000-0002-4313-4573","position":3,"is_corresponding":false},{"id":348066,"name":"Carol J. Wilusz","orcid":"0000-0001-9939-0747","position":4,"is_corresponding":false},{"id":348064,"name":"Adam Heck","orcid":"0000-0002-2485-759X","position":0,"is_corresponding":true}],"reference_count":97,"raw_metadata":null,"created_at":"2026-07-18T21:13:43.728351Z","pmid":"32169943","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}