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These results show that changing genes' 5′ UTR boundaries can produce large changes in protein output without changing the overall amount of mRNA. Because transcription start site (TSS) heterogeneity is common, we suggest that TSS choice is greatly under-appreciated as a quantitatively significant mechanism for regulating protein production.</jats:p>","journal":"RNA","year":2012,"id":33920,"datarank":4.87280641360787,"base_score":4.919980925828125,"endowment":4.919980925828125,"self_citation_contribution":0.7379971388742189,"citation_network_contribution":4.134809274733652,"self_endowment_contribution":0.7379971388742189,"citer_contribution":4.134809274733652,"corpus_percentile":null,"corpus_rank":null,"citation_count":136,"citer_count":127,"citers_with_citation_signal":110,"citers_with_endowment":110,"datacite_reuse_total":4,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":138500,"name":"Wendy V. 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Rojas-Duran","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.919980925828125,"endowment":4.919980925828125,"datacite_reuse_total":4,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23105001","pmcid":"PMC3504680","openalex_id":"https://openalex.org/W2171040119","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"K99 GM081399","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R00 GM081399","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"GM081399","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM094303","title":null}],"total_grants":4,"fwci":3.0899,"citation_percentile":0.92389547,"influential_citations":1,"citation_trend":[{"year":2013,"count":8},{"year":2014,"count":6},{"year":2015,"count":9},{"year":2016,"count":9},{"year":2017,"count":17},{"year":2018,"count":4},{"year":2019,"count":14},{"year":2020,"count":14},{"year":2021,"count":15},{"year":2022,"count":13},{"year":2023,"count":8},{"year":2024,"count":9},{"year":2025,"count":8},{"year":2026,"count":2}],"oa_status":"bronze","license":"cc-by-nc","oa_locations":[{"url":"http://rnajournal.cshlp.org/content/18/12/2299.full.pdf","host_type":"journal"},{"url":"http://rnajournal.cshlp.org/content/18/12/2299.full.pdf","host_type":"BRONZE"},{"url":"http://rnajournal.cshlp.org/content/18/12/2299.full.pdf","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1261/rna.035865.112","host_type":"publisher"},{"url":"https://doi.org/10.1261/rna.035865.112","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23105001","host_type":"repository"},{"url":"http://hdl.handle.net/1721.1/85841","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3504680","host_type":"repository"}],"fields_of_study":["RNA and protein synthesis mechanisms","RNA Research and Splicing","RNA modifications and cancer","Medicine","Biology"],"mesh_terms":["Base Sequence","Genes, Fungal","RNA Caps","RNA, Fungal","RNA, Messenger","Saccharomyces cerevisiae","Protein Biosynthesis","5' Untranslated Regions","RNA Splice Sites","Transcription Initiation Site","Riboswitch"],"keywords":["Biology","Five prime untranslated region","Untranslated region","Gene isoform","Messenger RNA","Translation (biology)","Gene","Translational regulation","Three prime untranslated region","Transcription (linguistics)","Genetics","Eukaryotic translation","Protein biosynthesis","Translational efficiency","Cell biology"],"sdg_mappings":[],"linked_datasets":[{"doi":"10.6084/m9.figshare.22606504.v1","title":"Additional file 5 of New insights into genome annotation in Podospora anserina through re-exploiting multiple RNA-seq data","publisher":"figshare","resource_type":"Presentation"},{"doi":"10.6084/m9.figshare.22606504","title":"Additional file 5 of New insights into genome annotation in Podospora anserina through re-exploiting multiple RNA-seq data","publisher":"figshare","resource_type":"Presentation"},{"doi":"10.6084/m9.figshare.22606495.v1","title":"Additional file 2 of New insights into genome annotation in Podospora anserina through re-exploiting multiple RNA-seq data","publisher":"figshare","resource_type":"Presentation"},{"doi":"10.6084/m9.figshare.22606495","title":"Additional file 2 of New insights into genome annotation in Podospora anserina through re-exploiting multiple RNA-seq data","publisher":"figshare","resource_type":"Presentation"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-09T17:12:20.818472Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}