{"doi":"10.1258/0004563001901524","title":"Adult reference ranges for serum cystatin C, creatinine and predicted creatinine clearance","abstract":"<jats:p>Serum cystatin C measurement has been previously shown by ourselves and others to be a better indicator of changes in glomerular filtration rate (GFR) than serum creatinine. However, the available literature on reference values for cystatin C concentration remains surprisingly sparse; we thus set out to determine an adult reference range. Blood was taken from 309 healthy blood donors and creatinine and cystatin C concentrations were measured using commercially available automated methodologies. In addition, predicted creatinine clearances were calculated using the Cockcroft and Gault formula. The 95% reference intervals for creatinine, predicted creatinine clearance and cystatin C for all blood donors, regardless of gender, were 68-118 µmol/L, 58-120 ml/min/1·73 m 2 and 0·51-0·98 mg/L, respectively. For women, the intervals were 68-98 µmol/L, 60-119 ml/min/1·73 m 2 and 0·49-0·94 mg/ L; for men, they were 78-123 µmol/L, 57-122 ml/min/1·73 m 2 and 0·56-0·98 mg/L. The mean 95% reference interval for cystatin C in all donors under 50 years of age was 0·53-0·92 mg/L; for those over 50 years of age it was 0·58-1·02 mg/L. The small difference between male and female ranges meant that a single reference range for cystatin C could be established for all adults under 50 years of age without adjustment for body surface area. Serum cystatin C measurement offers a simpler and more sensitive screening test than serum creatinine for early changes in GFR.</jats:p>","journal":"Annals of Clinical Biochemistry: International Journal of Laboratory Medicine","year":2000,"id":29278,"datarank":16.89809046946777,"base_score":5.6131281063880705,"endowment":5.6131281063880705,"self_citation_contribution":0.8419692159582107,"citation_network_contribution":16.05612125350956,"self_endowment_contribution":0.8419692159582107,"citer_contribution":16.05612125350956,"corpus_percentile":null,"corpus_rank":null,"citation_count":273,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":4,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":161804,"name":"David J Newman","orcid":null,"position":1,"is_corresponding":false},{"id":161805,"name":"Christopher P Price","orcid":null,"position":2,"is_corresponding":false},{"id":161803,"name":"Hazel Finney","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":5.6131281063880705,"endowment":5.6131281063880705,"datacite_reuse_total":4,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"10672373","pmcid":null,"openalex_id":"https://openalex.org/W2071643528","authors":[],"funders":[],"total_grants":0,"fwci":6.7166,"citation_percentile":0.9747805,"influential_citations":5,"citation_trend":[{"year":2012,"count":16},{"year":2013,"count":12},{"year":2014,"count":11},{"year":2015,"count":12},{"year":2016,"count":13},{"year":2017,"count":4},{"year":2018,"count":7},{"year":2019,"count":7},{"year":2020,"count":12},{"year":2021,"count":12},{"year":2022,"count":12},{"year":2023,"count":13},{"year":2024,"count":9},{"year":2025,"count":5},{"year":2026,"count":2}],"oa_status":"closed","license":"https://journals.sagepub.com/page/policies/text-and-data-mining-license","oa_locations":[{"url":"https://journals.sagepub.com/doi/pdf/10.1258/0004563001901524","host_type":"publisher"},{"url":"https://doi.org/10.1258/0004563001901524","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/10672373","host_type":"repository"}],"fields_of_study":["Chronic Kidney Disease and Diabetes","Dialysis and Renal Disease Management","Renal and Vascular Pathologies","Medicine","Adult","Clinical Laboratory Techniques","Creatinine","Cystatin C","Cystatins","Female","Humans","Male","Middle Aged","Predictive Value of Tests","Reference Standards"],"mesh_terms":["Adult","Creatinine","Female","Humans","Male","Middle Aged","Predictive Value of Tests","Reference Standards","Cystatins","Clinical Laboratory Techniques","Cystatin C"],"keywords":["Creatinine","Cystatin C","Renal function","Cystatin","Urology","Reference range","Confidence interval","Endocrinology","Medicine","Chemistry","Internal medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.12667899.v1","title":"Additional file 1 of Discrepant glomerular filtration rate trends from creatinine and cystatin C in patients with chronic kidney disease: results from the KNOW-CKD cohort","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.12667899","title":"Additional file 1 of Discrepant glomerular filtration rate trends from creatinine and cystatin C in patients with chronic kidney disease: results from the KNOW-CKD cohort","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.22622830.v1","title":"Additional file 1 of Onset timing and duration of augmented renal clearance in a mixed intensive care unit","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.22622830","title":"Additional file 1 of Onset timing and duration of augmented renal clearance in a mixed intensive care unit","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-08T23:01:49.605756Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}