{"doi":"10.1254/fpj.99.401","title":"Effects of FRG-8813, a new type histamine H2-receptor antagonist, on various experimental gastric and duodenal lesions in rats.","abstract":null,"journal":"Folia Pharmacologica Japonica","year":1992,"id":681099,"datarank":0.42498200160843247,"base_score":2.833213344056216,"endowment":2.833213344056216,"self_citation_contribution":0.42498200160843247,"citation_network_contribution":0.0,"self_endowment_contribution":0.42498200160843247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1779519,"name":"Masahiro SHIBATA","orcid":null,"position":1,"is_corresponding":false},{"id":1779520,"name":"Niro INABA","orcid":null,"position":2,"is_corresponding":false},{"id":1779521,"name":"Sadayoshi ONODERA","orcid":null,"position":3,"is_corresponding":false},{"id":1779522,"name":"Yuriko CHIDA","orcid":null,"position":4,"is_corresponding":false},{"id":1779523,"name":"Haruo OHNISHI","orcid":null,"position":5,"is_corresponding":false},{"id":1779518,"name":"Tetsuaki YAMAURA","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Effects of FRG-8813, a new type histamine H2-receptor antagonist, on various experimental gastric and duodenal lesions in rats.","abstract":"We examined the anti-ulcer effects of FRG-8813, a new type histamine H2-receptor antagonist, on various experimental gastric and duodenal lesions in rats. FRG-8813, administered orally, inhibited the formation of lesions dose-dependently in experimental models with the exception of the Shay ulcer model. The anti-ulcer potency of FRG-8813 was 4 approximately 10 times greater than that of cimetidine when the ED50 values of both compounds were compared. Famotidine and cimetidine inhibited lesion formation at higher doses than the anti-secretory doses. The anti-ulcer action of FRG-8813, however, appeared at even lower doses than those of anti-secretory action. These results suggest that FRG-8813 is able to prevent lesion formation with anti-secretory action plus other mechanisms unlike typical histamine H2-receptor antagonists.","is_dataset_classified":null,"base_score":2.833213344056216,"endowment":2.833213344056216,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"1356897","pmcid":null,"openalex_id":"https://openalex.org/W2020459612","authors":[],"funders":[],"total_grants":0,"fwci":0.4194,"citation_percentile":0.56796307,"influential_citations":0,"citation_trend":[{"year":2014,"count":1},{"year":2016,"count":1}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://www.jstage.jst.go.jp/article/fpj1944/99/6/99_6_401/_pdf","host_type":"journal"},{"url":"https://www.jstage.jst.go.jp/article/fpj1944/99/6/99_6_401/_pdf","host_type":"publisher"},{"url":"https://doi.org/10.1254/fpj.99.401","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/1356897","host_type":"repository"}],"fields_of_study":["Receptor Mechanisms and Signaling","Mast cells and histamine","Neuropeptides and Animal Physiology"],"mesh_terms":["Acetamides","Animals","Disease Models, Animal","Dose-Response Relationship, Drug","Duodenal Ulcer","Gastric Acid","Histamine H2 Antagonists","Male","Piperidines","Pyridines","Stomach Ulcer","Rats, Wistar","Rats"],"keywords":["Histamine","Histamine H2 receptor","Antagonist","Pharmacology","Internal medicine","Medicine","Chemistry","Gastroenterology","Endocrinology","Receptor"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T16:56:31.653608Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}