{"doi":"10.1253/circj.cj-24-0762","title":"Contribution of Seasonal Variation and Inflammation to Increased In-Hospital Events and Early Mortality in Patients With Takotsubo Syndrome","abstract":null,"journal":"Circulation Journal","year":2025,"id":608693,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1292699,"name":"Kensuke Matsushita","orcid":"0000-0002-3722-2921","position":1,"is_corresponding":false},{"id":1464748,"name":"Antonin Trimaille","orcid":"0000-0001-9279-4220","position":2,"is_corresponding":false},{"id":1563617,"name":"Shinnosuke Kikuchi","orcid":null,"position":3,"is_corresponding":false},{"id":1563618,"name":"Taraneh Tatarcheh","orcid":null,"position":4,"is_corresponding":false},{"id":1563619,"name":"Benjamin Marchandot","orcid":null,"position":5,"is_corresponding":false},{"id":1563620,"name":"Amandine Granier","orcid":null,"position":6,"is_corresponding":false},{"id":1563621,"name":"Loic Faucher","orcid":null,"position":7,"is_corresponding":false},{"id":1563622,"name":"Valerie Schini-Kerth","orcid":null,"position":8,"is_corresponding":false},{"id":1563623,"name":"Patrick Ohlmann","orcid":null,"position":9,"is_corresponding":false},{"id":1563624,"name":"Laurence Jesel","orcid":null,"position":10,"is_corresponding":false},{"id":667400,"name":"Oliver Morel","orcid":null,"position":11,"is_corresponding":false},{"id":1563616,"name":"Maximilien Martz","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Contribution of Seasonal Variation and Inflammation to Increased In-Hospital Events and Early Mortality in Patients With Takotsubo Syndrome","abstract":"BACKGROUND: Initially regarded as a benign acute cardiomyopathy, recent insights have shown that takotsubo syndrome (TTS) carries a prognosis comparable to that of acute coronary syndrome, with a notable impact of inflammatory burden. Given the seasonal variation seen in air pollution, inflammation, and coronary events, we investigated whether chronobiology and inflammation contribute to adverse outcomes. METHODS AND RESULTS: Between 2008 and 2020, all consecutive TTS patients were retrospectively included in a multicenter registry. We analyzed the impact of seasonal variation and inflammation on in-hospital events, including acute cardiac failure, cardiogenic shock, and death, as well as 30-day mortality. In-hospital events were identified in 238 (42.6%) patients. Higher rates of in-hospital events and 30-day mortality were observed during winter and spring than in summer and autumn. Multivariate analysis identified the presence of dyspnea on admission (odds ratio [OR] 4.02; 95% confidence interval [CI] 2.61-6.17; P<0.001), a neurological trigger (OR 2.58; 95% CI 1.21-5.50; P=0.014), hyperleukocytosis (OR 1.04; 95% CI 1.02-1.17; P=0.002), and left ventricular ejection fraction at admission (OR 0.98; 95% CI 0.96-1.00; P=0.011) as independent predictors of adverse outcomes. CONCLUSIONS: In TTS, higher rates of in-hospital events and 30-day mortality were observed during winter and spring. Inflammatory burden and neurological disorders emerged as independent predictors of poor prognosis.","is_dataset_classified":null,"base_score":1.791759469228055,"endowment":1.791759469228055,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40533164","pmcid":null,"openalex_id":"https://openalex.org/W4411406518","authors":[],"funders":[],"total_grants":0,"fwci":4.467,"citation_percentile":0.95027888,"influential_citations":0,"citation_trend":[{"year":2026,"count":5}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://www.jstage.jst.go.jp/article/circj/advpub/0/advpub_CJ-24-0762/_pdf","host_type":"journal"},{"url":"https://www.jstage.jst.go.jp/article/circj/advpub/0/advpub_CJ-24-0762/_pdf","host_type":"publisher"},{"url":"https://www.jstage.jst.go.jp/article/circj/89/10/89_CJ-24-0762/_pdf","host_type":"publisher"},{"url":"https://doi.org/10.1253/circj.cj-24-0762","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40533164","host_type":"repository"},{"url":"https://univoak.hal.science/hal-05333537","host_type":"repository"},{"url":"https://univoak.hal.science/hal-05333537v1/file/Contribution%20of%20seasonal.pdf","host_type":"repository"}],"fields_of_study":["Takotsubo Cardiomyopathy and Associated Phenomena","Cardiovascular and Diving-Related Complications","Coronary Artery Anomalies"],"mesh_terms":["Aged","Aged, 80 and over","Female","Humans","Inflammation","Male","Middle Aged","Prognosis","Registries","Retrospective Studies","Risk Factors","Seasons","Hospital Mortality","Takotsubo Cardiomyopathy"],"keywords":["Medicine","Acute coronary syndrome","Internal medicine","Cardiogenic shock","Odds ratio","Confidence interval","Ejection fraction","Cardiomyopathy","Cardiology","Heart failure","Adverse effect","Myocardial infarction","Mortality","Inflammation","Cardiovascular Outcome","Chronobiology","Takotsubo Syndrome"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T20:21:22.291958Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}