{"doi":"10.1253/circj.cj-20-0862","title":"Polarimetric Signatures of Coronary Thrombus in Patients With Acute Coronary Syndrome","abstract":"BACKGROUND: Intravascular polarization-sensitive optical frequency domain imaging (PS-OFDI) offers a novel approach to measure tissue birefringence, which is elevated in collagen and smooth muscle cells, that in turn plays a critical role in healing coronary thrombus (HCT). This study aimed to quantitatively assess polarization properties of coronary fresh and organizing thrombus with PS-OFDI in patients with acute coronary syndrome (ACS). METHODS AND RESULTS: The POLARIS-I prospective registry enrolled 32 patients with ACS. Pre-procedural PS-OFDI pullbacks using conventional imaging catheters revealed 26 thrombus-regions in 21 patients. Thrombus was manually delineated in conventional OFDI cross-sections separated by 0.5 mm and categorized into fresh thrombus caused by plaque rupture, stent thrombosis, or erosion in 18 thrombus-regions (182 frames) or into HCT for 8 thrombus-regions (141 frames). Birefringence of coronary thrombus was compared between the 2 categories. Birefringence in HCTs was significantly higher than in fresh thrombus (∆n=0.47 (0.37-0.72) vs. ∆n=0.25 (0.17-0.29), P=0.007). In a subgroup analysis, when only using thrombus-regions from culprit lesions, ischemic time was a significant predictor for birefringence (ß (∆n)=0.001 per hour, 95% CI [0.0002-0.002], P=0.023). CONCLUSIONS: Intravascular PS-OFDI offers the opportunity to quantitatively assess the polarimetric properties of fresh and organizing coronary thrombus, providing new insights into vascular healing and plaque stability.","journal":"Circulation Journal","year":2021,"id":196052,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9606,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":506533,"name":"Kenichiro Otsuka","orcid":"0000-0003-1359-3143","position":1,"is_corresponding":false},{"id":369743,"name":"Martin Villiger","orcid":"0000-0003-3819-1271","position":2,"is_corresponding":false},{"id":533575,"name":"Tara Neleman","orcid":"0000-0003-4583-4175","position":3,"is_corresponding":false},{"id":533577,"name":"Jouke Dijkstra","orcid":"0000-0002-8666-3731","position":4,"is_corresponding":false},{"id":637617,"name":"Felix Zijlstra","orcid":null,"position":5,"is_corresponding":false},{"id":768052,"name":"Nicolas M. Van Mieghem","orcid":"0000-0002-2732-1205","position":6,"is_corresponding":false},{"id":247839,"name":"Brett E. Bouma","orcid":"0000-0002-4531-2206","position":7,"is_corresponding":false},{"id":768053,"name":"Joost Daemen","orcid":"0000-0001-9081-5518","position":8,"is_corresponding":false},{"id":533574,"name":"Laurens J.C. van Zandvoort","orcid":"0000-0002-8618-0318","position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":null,"created_at":"2026-07-18T23:50:11.609550Z","pmid":"33828020","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}