{"doi":"10.1253/circj.cj-17-0510","title":"Long-Term Clinical Outcomes Survey of Bone Marrow-Derived Cell Therapy in Critical Limb Ischemia in Japan","abstract":null,"journal":"Circulation Journal","year":2018,"id":46784,"datarank":1.5732439638848947,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"self_citation_contribution":0.5606504427425053,"citation_network_contribution":1.0125935211423895,"self_endowment_contribution":0.5606504427425053,"citer_contribution":1.0125935211423895,"corpus_percentile":null,"corpus_rank":null,"citation_count":41,"citer_count":25,"citers_with_citation_signal":23,"citers_with_endowment":23,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":128884,"name":"Kenji Yanishi","orcid":null,"position":1,"is_corresponding":false},{"id":216404,"name":"Ryo Hayashida","orcid":null,"position":2,"is_corresponding":false},{"id":216405,"name":"Satoshi Shintani","orcid":null,"position":3,"is_corresponding":false},{"id":216406,"name":"Rei Shibata","orcid":null,"position":4,"is_corresponding":false},{"id":216407,"name":"Kenta Murotani","orcid":null,"position":5,"is_corresponding":false},{"id":216408,"name":"Masahiko Ando","orcid":"0000-0002-5481-3782","position":6,"is_corresponding":false},{"id":216409,"name":"Masaaki Mizuno","orcid":null,"position":7,"is_corresponding":false},{"id":216410,"name":"Tadami Fujiwara","orcid":null,"position":8,"is_corresponding":false},{"id":87066,"name":"Toyoaki Murohara","orcid":"0000-0003-2723-6243","position":9,"is_corresponding":false},{"id":128892,"name":"Satoaki Matoba","orcid":null,"position":10,"is_corresponding":false},{"id":216403,"name":"Kazuhisa Kondo","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Long-Term Clinical Outcomes Survey of Bone Marrow-Derived Cell Therapy in Critical Limb Ischemia in Japan","abstract":"BACKGROUND: The Therapeutic Angiogenesis by Cell Transplantation (TACT) trial demonstrated the efficacy and safety of autologous bone marrow-derived mononuclear cells (BM-MNCs) in patients with critical limb ischemia (CLI). The present study aimed to assess the long-term clinical outcomes of therapeutic angiogenesis using autologous BM-MNC implantation under advanced medical treatment in Japan. METHODS AND RESULTS: The study was retrospective, observational, and non-controlled. We assessed no-option CLI patients who had BM-MNC implantation performed in 10 institutes. Overall survival (OS), major amputation-free (MAF), and amputation-free survival (AFS) rates were primary endpoints of this study. The median follow-up duration was 31.7 months. The 10-year OS rate was 46.6% in patients with arteriosclerosis obliterans (ASO) (n=168), 90.5% in patients with thromboangiitis obliterans (TAO) (n=108), and 67.6% in patients with collagen disease-associated vasculitis (CDV) (n=69). The 10-year MAF rate was 70.1%, 87.9%, and 90.9%, respectively. The 10-year AFS rate was 37.8%, 80.9%, and 61.2%, respectively. Major adverse cardiovascular events occurred in 6.0% of patients with ASO, 1.9% of patients with TAO, and no patients with CDV. CONCLUSIONS: Therapeutic angiogenesis using autologous BM-MNC implantation may be feasible and safe in patients with no-option CLI, particularly those with CLI caused by TAO or CDV.","is_dataset_classified":null,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29386474","pmcid":null,"openalex_id":"https://openalex.org/W2791362877","authors":[],"funders":[],"total_grants":0,"fwci":2.5054,"citation_percentile":0.90076435,"influential_citations":0,"citation_trend":[{"year":2018,"count":2},{"year":2019,"count":8},{"year":2020,"count":13},{"year":2021,"count":4},{"year":2022,"count":4},{"year":2023,"count":5},{"year":2025,"count":3},{"year":2026,"count":2}],"oa_status":"gold","license":null,"oa_locations":[{"url":"https://www.jstage.jst.go.jp/article/circj/82/4/82_CJ-17-0510/_pdf","host_type":"journal"},{"url":"https://www.jstage.jst.go.jp/article/circj/82/4/82_CJ-17-0510/_pdf","host_type":"GOLD"},{"url":"https://www.jstage.jst.go.jp/article/circj/82/4/82_CJ-17-0510/_pdf","host_type":"publisher"},{"url":"https://doi.org/10.1253/circj.cj-17-0510","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29386474","host_type":"repository"}],"fields_of_study":["Angiogenesis and VEGF in Cancer","Peripheral Artery Disease Management","Mesenchymal stem cell research","Medicine","Adult","Aged","Amputation, Surgical","Bone Marrow Cells","Cell- and Tissue-Based Therapy","Extremities","Female","Humans","Ischemia","Japan","Leukocytes, Mononuclear","Longitudinal Studies","Male","Middle Aged","Neovascularization, Physiologic","Retrospective Studies","Surveys and Questionnaires","Survival Rate","Transplantation, Autologous","Treatment Outcome"],"mesh_terms":["Adult","Aged","Amputation, Surgical","Bone Marrow Cells","Extremities","Female","Humans","Ischemia","Japan","Leukocytes, Mononuclear","Longitudinal Studies","Male","Middle Aged","Surveys and Questionnaires","Retrospective Studies","Transplantation, Autologous","Survival Rate","Treatment Outcome","Neovascularization, Physiologic","Cell- and Tissue-Based Therapy"],"keywords":["Therapeutic angiogenesis","Critical limb ischemia","Medicine","Angiogenesis","Tact","Bone marrow","Peripheral blood mononuclear cell","Ischemia","Oncology","Cell therapy","Clinical trial","Surgery","Internal medicine","Neovascularization","Cell","Vascular disease","Arterial disease","Bone Marrow-derived Mononuclear Cells"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-14T01:40:03.484429Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}