{"doi":"10.1253/circj.72.509","title":"Ryanodine Receptor as a New Therapeutic Target of Heart Failure and Lethal Arrhythmia","abstract":null,"journal":"Circulation Journal","year":2007,"id":628040,"datarank":0.5375278407684165,"base_score":3.58351893845611,"endowment":3.58351893845611,"self_citation_contribution":0.5375278407684165,"citation_network_contribution":0.0,"self_endowment_contribution":0.5375278407684165,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":35,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1409428,"name":"Masafumi Yano","orcid":"0000-0001-7425-1820","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Ryanodine Receptor as a New Therapeutic Target of Heart Failure and Lethal Arrhythmia","abstract":"Abnormal intracellular Ca(2+) handling by the sarcoplasmic reticulum (SR) is a critical factor in the development of heart failure (HF). Not only decreased Ca(2+) uptake, but also uncoordinated Ca(2+) release plays a significant role in contractile and relaxation dysfunction. Spontaneous Ca(2+) release through ryanodine receptor (RyR) 2, a huge tetrameric protein, during diastole leads to a decrease in the SR Ca(2+) content, and also triggers delayed after depolarization that is a substrate for lethal arrhythmia. Several disease-linked mutations of RyR have been reported in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT) or arrhythmogenic right ventricular cardiomyopathy type 2 (ARVC2). The unique distribution of these mutation sites has lead to the concept that an interaction among the putative regulatory domains within RyR may play a key role in regulating channel opening, and that there seems to be a common abnormality in the channel disorder of HF and CPVT/ARVC2. Recent knowledge gained from pathological conditions may lead to the development of a new therapeutic strategy for the treatment of HF or cardiac arrhythmia.","is_dataset_classified":null,"base_score":3.58351893845611,"endowment":3.58351893845611,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18362417","pmcid":null,"openalex_id":"https://openalex.org/W2016503231","authors":[],"funders":[],"total_grants":0,"fwci":2.4633,"citation_percentile":0.89455773,"influential_citations":0,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":3},{"year":2014,"count":4},{"year":2015,"count":2},{"year":2016,"count":1},{"year":2017,"count":1},{"year":2020,"count":1},{"year":2022,"count":1},{"year":2023,"count":1},{"year":2025,"count":1}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://www.jstage.jst.go.jp/article/circj/72/4/72_4_509/_pdf","host_type":"journal"},{"url":"https://www.jstage.jst.go.jp/article/circj/72/4/72_4_509/_pdf","host_type":"publisher"},{"url":"http://www.jstage.jst.go.jp/article/circj/72/4/72_4_509/_pdf","host_type":"publisher"},{"url":"https://doi.org/10.1253/circj.72.509","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/18362417","host_type":"repository"}],"fields_of_study":["Cardiac electrophysiology and arrhythmias","Ion channel regulation and function","Neuroscience and Neuropharmacology Research","Animals","Arrhythmias, Cardiac","Calcium Signaling","Calcium-Calmodulin-Dependent Protein Kinase Type 2","Heart Failure","Humans","Ion Channel Gating","Models, Cardiovascular","Models, Molecular","Mutation","Protein Interaction Domains and Motifs","Ryanodine Receptor Calcium Release Channel"],"mesh_terms":["Animals","Arrhythmias, Cardiac","Heart Failure","Humans","Models, Cardiovascular","Models, Molecular","Mutation","Ion Channel Gating","Ryanodine Receptor Calcium Release Channel","Calcium Signaling","Protein Interaction Domains and Motifs","Calcium-Calmodulin-Dependent Protein Kinase Type 2"],"keywords":["Ryanodine receptor","Heart failure","Cardiac arrhythmia","Cardiology","Internal medicine","Receptor","Medicine","Atrial fibrillation"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T10:50:06.851814Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}