{"doi":"10.1248/bpb.b12-01032","title":"The Polymerization Agent, 2-Methyl-4′-(methylthio)-2-morpholinopropiophenone Induces Caspases-3/7 in Human Blood Mononuclear Cells <i>in Vitro</i>","abstract":null,"journal":"Biological and Pharmaceutical Bulletin","year":2013,"id":682442,"datarank":0.3596842909197557,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.0,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1782900,"name":"Kenta Yagi","orcid":null,"position":1,"is_corresponding":false},{"id":1782901,"name":"Chiaki Tsuboi","orcid":null,"position":2,"is_corresponding":false},{"id":1782902,"name":"Miwa Morizane","orcid":null,"position":3,"is_corresponding":false},{"id":1778843,"name":"Yoshihisa Kitamura","orcid":null,"position":4,"is_corresponding":false},{"id":1782903,"name":"Toshiaki Sendo","orcid":null,"position":5,"is_corresponding":false},{"id":1782899,"name":"Yoichi Kawasaki","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The Polymerization Agent, 2-Methyl-4′-(methylthio)-2-morpholinopropiophenone Induces Caspases-3/7 in Human Blood Mononuclear Cells <i>in Vitro</i>","abstract":"Our previous studies detected the presence of a photoinitiator 2-methyl-4'-(methylthio)-2-morpholinopropiophenone (MTMP) in an intravenous (i.v.) injection bag solution. Importantly, MTMP has demonstrated cytotoxicity for normal human peripheral blood (PB) mononuclear cells (MNC). Cell death pathways have two well-known modes, apoptosis and necrosis. But it has not been clear whether MTMP induced apoptosis or necrosis in normal human PB MNC. In the present in vitro study, we examined normal human PB MNC for the frequencies of apoptosis and necrosis and changes upon exposure to MTMP. We observed time-dependent changes in MNC viability with MTMP. We also assessed the activity of caspases-3/7. The results demonstrated that MTMP induced apoptosis in normal human PB MNC after 24 h. In addition, MTMP induced caspases-3/7 in a time-dependent manner. In conclusion, we suggest that MTMP induces apoptosis in a caspase-dependent pathway in vitro.","is_dataset_classified":null,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24088257","pmcid":null,"openalex_id":"https://openalex.org/W2011179920","authors":[],"funders":[],"total_grants":0,"fwci":0.9368,"citation_percentile":0.75262324,"influential_citations":0,"citation_trend":[{"year":2014,"count":1},{"year":2015,"count":1},{"year":2016,"count":1},{"year":2018,"count":1},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2022,"count":1},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"gold","license":null,"oa_locations":[{"url":"https://doi.org/10.1248/bpb.b12-01032","host_type":"journal"},{"url":"https://doi.org/10.1248/bpb.b12-01032","host_type":"publisher"},{"url":"https://www.jstage.jst.go.jp/article/bpb/36/10/36_b12-01032/_pdf","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/24088257","host_type":"repository"}],"fields_of_study":["Skin Protection and Aging","Retinoids in leukemia and cellular processes","Photodynamic Therapy Research Studies"],"mesh_terms":["Cell Survival","Humans","Leukocytes, Mononuclear","Morpholines","Necrosis","Propiophenones","Apoptosis","Caspase 3","Caspase 7","Polymerization"],"keywords":["Peripheral blood mononuclear cell","Apoptosis","In vitro","Caspase","Necrosis","Cytotoxicity","Chemistry","Intrinsic apoptosis","Tumor necrosis factor alpha","Programmed cell death","Viability assay","Molecular biology","Cell biology","Biology","Immunology","Biochemistry","Medicine","Pathology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T20:23:41.883871Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}