{"doi":"10.1248/bpb.29.813","title":"The Effects of BR003 on Memory and Cell Proliferation in the Dentate Gyrus of Rat Hippocampus","abstract":null,"journal":"Biological and Pharmaceutical Bulletin","year":2006,"id":592740,"datarank":0.35068492226647585,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.08192100188226759,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.08192100188226759,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":4,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":113986,"name":"Chan Park","orcid":null,"position":1,"is_corresponding":false},{"id":1516861,"name":"Youngbuhm Huh","orcid":null,"position":2,"is_corresponding":false},{"id":568576,"name":"Hong-Yeoul Kim","orcid":"0000-0003-3018-0316","position":3,"is_corresponding":false},{"id":1516862,"name":"Hocheol Kim","orcid":null,"position":4,"is_corresponding":false},{"id":1516863,"name":"Hyung-Min Kim","orcid":null,"position":5,"is_corresponding":false},{"id":1516864,"name":"Hyunsu Bae","orcid":null,"position":6,"is_corresponding":false},{"id":1516865,"name":"Duk Kyun Ahn","orcid":null,"position":7,"is_corresponding":false},{"id":1516866,"name":"Wan-Su Park","orcid":null,"position":8,"is_corresponding":false},{"id":1516867,"name":"Seong Kyu Park","orcid":null,"position":9,"is_corresponding":false},{"id":304766,"name":"Myung Sook Oh","orcid":"0000-0001-8189-4066","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The Effects of BR003 on Memory and Cell Proliferation in the Dentate Gyrus of Rat Hippocampus","abstract":"BR003 is a multi-herbal formula that contains twelve medicinal herbs. We investigated the effects of oral administration of BR003 to Wistar rats on (a) learning and memory using a passive avoidance test and (b) cell proliferation in the dentate gyrus (DG) of the hippocampus using immunohistochemical analysis of 5-bromo-2-deoxyuridine (BrdU) expression. In the passive avoidance test, the retention time of the BR003-treated group was significantly longer than that of the control group (182.64+/-39.88 vs. 73.08+/-29.30 s, respectively; n=11; p<0.05). There were significantly more BrdU-immunoreactive cells in the DG in the BR003-treated group than in the control group (1281.07+/-151.16 vs. 818.01+/-132.98 cells per DG, respectively; n=11; p<0.05). These results suggest that the administration of BR003 not only improves learning and memory but also increases cell proliferation in the DG of the rat hippocampus.","is_dataset_classified":null,"base_score":1.791759469228055,"endowment":1.791759469228055,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16595925","pmcid":null,"openalex_id":"https://openalex.org/W1987589144","authors":[],"funders":[],"total_grants":0,"fwci":0.2313,"citation_percentile":0.44817419,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2014,"count":1},{"year":2020,"count":1}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://www.jstage.jst.go.jp/article/bpb/29/4/29_4_813/_pdf","host_type":"journal"},{"url":"https://www.jstage.jst.go.jp/article/bpb/29/4/29_4_813/_pdf","host_type":"BRONZE"},{"url":"https://www.jstage.jst.go.jp/article/bpb/29/4/29_4_813/_pdf","host_type":"publisher"},{"url":"http://www.jstage.jst.go.jp/article/bpb/29/4/29_4_813/_pdf","host_type":"publisher"},{"url":"https://doi.org/10.1248/bpb.29.813","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16595925","host_type":"repository"}],"fields_of_study":["Neuroscience and Neuropharmacology Research","Neurogenesis and neuroplasticity mechanisms","Anesthesia and Neurotoxicity Research","Medicine","Biology","Animals","Antimetabolites","Avoidance Learning","Bromodeoxyuridine","Cell Proliferation","Dentate Gyrus","Drugs, Chinese Herbal","Immunohistochemistry","Male","Memory","Nootropic Agents","Rats","Rats, Wistar","Stimulation, Chemical"],"mesh_terms":["Animals","Antimetabolites","Avoidance Learning","Bromodeoxyuridine","Drugs, Chinese Herbal","Immunohistochemistry","Male","Memory","Stimulation, Chemical","Rats, Wistar","Nootropic Agents","Dentate Gyrus","Cell Proliferation","Rats"],"keywords":["Dentate gyrus","Hippocampus","Immunohistochemistry","Cell growth","Internal medicine","Medicine","Endocrinology","Bromodeoxyuridine","Chemistry","Pharmacology","Neuroscience","Biology","Biochemistry"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-26T15:19:36.684335Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}